Evidence map›Paper›PMID 36913680›Full record

SynthesisArchives of endocrinology and metabolism2023

Is the vitamin D status of patients with COVID-19 associated with reduced mortality? A systematic review and meta-analysis.

Paulo R Bignardi, Paula de Andrade Castello, Bruno de Matos Aquino, Vinicius Daher Alvares Delfino

Open access · diamondAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Archives of endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Severe COVID-19: Drugs and Clinical Trials.Journal of clinical medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Paulo R BignardiFaculdade de Medicina, Pontifícia Universidade Católica do Paraná, Londrina, PR, Brasil, pbignardi@gmail.com.
Paula de Andrade CastelloFaculdade de Medicina, Pontifícia Universidade Católica do Paraná, Londrina, PR, Brasil.
Bruno de Matos AquinoFaculdade de Medicina, Pontifícia Universidade Católica do Paraná, Londrina, PR, Brasil.
Vinicius Daher Alvares DelfinoFaculdade de Medicina, Pontifícia Universidade Católica do Paraná, Londrina, PR, Brasil.
Pontifícia Universidade Católica do Paraná · BRUniversidade Estadual de Londrina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To conduct a systematic review and meta-analysis of studies assessing the association between serum vitamin D status and mortality in patients with COVID- 19. We searched PubMed and Embase for studies addressing the association of serum vitamin D levels and COVID-19 mortality published until April 24, 2022. Risk ratios (RRs) and 95% confidence interval (CIs) were pooled using fixed or random effects models. The risk of bias was assessed using the Newcastle-Ottawa Scale. The meta-analysis included 21 studies that measured serum vitamin D levels close to the date of admission, of which 2 were case-control and 19 were cohort studies. Vitamin D deficiency was associated with COVID-19 mortality in the overall analysis but not when the analysis was adjusted to vitamin D cutoff levels < 10 or < 12 ng/mL (RR 1.60, 95% CI 0.93-2.27, I

Indexed as

COVID-19Vitamin D DeficiencyHumansVitamin DVitaminsVitamin DVitamins1,25-dihydroxyvitamin D25-hydroxyvitamin Dmeta-analysisSARS-CoV-2systematic review

Identifiers

PMID36913680
PMCPMC10689034
OpenAlexW4319297191

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.