Evidence map›Paper›PMID 36914787›Full record

ArticleJournal of neurology2023

The influence of culture and cognitive reserve on the clinical presentation of behavioural-variant frontotemporal dementia.

A Skeggs, G Wei, R Landin-Romero, J R Hodges, O Piguet, Fiona Kumfor

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Cognitive reserve in individuals with frontotemporal dementia: a systematic review.Journal of clinical and experimental neuropsychology · 2024
    Pooled it
  2. Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

A SkeggsSchool of Psychology, The University of Sydney, Sydney, NSW, 2006, Australia.
G WeiSchool of Psychology, The University of Sydney, Sydney, NSW, 2006, Australia.
R Landin-RomeroSchool of Psychology, The University of Sydney, Sydney, NSW, 2006, Australia.
J R HodgesBrain and Mind Centre, The University of Sydney, 94 Mallett Street Camperdown, Sydney, NSW, 2050, Australia.
O PiguetSchool of Psychology, The University of Sydney, Sydney, NSW, 2006, Australia.
Fiona KumforSchool of Psychology, The University of Sydney, Sydney, NSW, 2006, Australia. fiona.kumfor@sydney.edu.au.ORCID http://orcid.org/0000-0002-3208-075X
The University of Sydney · AU

Funding

ARC Centre of Excellence in Cognition and its Disorders CE11000102Dementia Research Team Grant 1095127National Health and Medical Research Council 1132524National Health and Medical Research Council GNT1158762National Health and Medical Research Council GNT2008020National Health and Medical Research Council GNT2010064
6 · The paper itself

Abstract

Characterisation of the clinical profile of behavioural-variant frontotemporal dementia (bvFTD) has predominantly been based on Western samples. Some small studies have suggested that the clinical profile may differ in culturally and linguistically diverse populations. Additionally, there is evidence that patients from non-English speaking backgrounds may have more cognitive reserve, allowing them to tolerate more disease pathology before clinical symptoms emerge. This study aims to characterise the clinical profiles of patients with bvFTD from culturally diverse backgrounds. BvFTD patients were classified as Australian-born (Australian) or Culturally and Linguistically Diverse-English-speaking (CALD-English) and Culturally and Linguistically Diverse-Language Other Than English (CALD-LOTE). Clinical features, cognitive test performance and cognitive reserve were compared between groups. Voxel-based morphometry was used to examine the neural correlates of cognitive reserve. 107 patients with bvFTD (53 Australian, 36 CALD-English, 18 CALD-LOTE) and 51 controls were included. Analysis of neuropsychiatric features revealed more elation in Australian patients compared to CALD-English patients, with trends for CALD-LOTE patients to report more irritability. CALD-LOTE patients also had higher cognitive reserve and showed relatively greater verbal than non-verbal cognitive impairment. Neuroimaging analyses revealed that higher cognitive reserve was associated with lower integrity in the frontal-temporal regions associated with typical disease pathology in bvFTD. Our findings support the hypothesis that cognitive reserve may delay early cognitive decline in culturally and linguistically diverse patients, although these patients may still show poor verbal performance due to cultural testing biases. Clinically, these results highlight the need to consider cultural and linguistic background to inform the assessment of dementia.

Indexed as

Cognitive ReserveFrontotemporal DementiaAustraliaHumansLanguageBehavioural-variant frontotemporal dementiaCulturally and linguistically diverseDiagnosisLanguagePresentationSocial cognition

Identifiers

PMID36914787
PMCPMC10188392
OpenAlexW4324025865

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.