Evidence map›Paper›PMID 36915130›Full record

ArticleBMC medicine2023

Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study.

Oliver M Shannon, Janice M Ranson, Sarah Gregory, Helen Macpherson, Catherine Milte, Marleen Lentjes, Angela Mulligan, Claire McEvoy, Alex Griffiths, Jamie Matu and 9 more

Registry-linked trialOpen access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06933212 (Effetto Della DIETa mEdiTerranea Sull'Incidenza di Ictus e Sul Decadimento Cognitivo in Pazienti Affetti da Cadasil e Angiopatia Cerebrale Amiloide), which is not on this map. Cited by 100 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 4 pooled it
42.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06933212 recruitingnot on this mapstarted 2024, after this paper: background citation

Effetto Della DIETa mEdiTerranea Sull'Incidenza di Ictus e Sul Decadimento Cognitivo in Pazienti Affetti da Cadasil e Angiopatia Cerebrale Amiloide

TypeobservationalSponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaRan2024 to 2026Enrolled86ConditionsCerebral Amyloid Angiopathy, CAA - Cerebral Amyloid AngiopathyArmsMediterranean Diet with Extra Virgin Olive Oil, Mediterranean Diet with Walnuts, Low-Fat Control Diet
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 4 syntheses or guidelines pooled it, 145 citations in OpenAlex.

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  17. Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  18. King Oyster Mushroom,Nutrients · 2026
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 4 countries.

Oliver M Shannon *Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Janice M Ranson *College of Medicine and Health, University of Exeter, Exeter, UK.
Sarah GregoryEdinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Helen MacphersonInstitute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia.
Catherine MilteInstitute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia.
Marleen LentjesSchool of Medical Sciences, Örebro University, Örebro, Sweden.
Angela MulliganNutrition Measurement Platform, MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Claire McEvoyCentre for Public Health, The Institute for Global Food Security, Queen's University Belfast, Belfast, UK.
Alex GriffithsSchool of Health, Leeds Beckett University, Leeds, UK.
Jamie MatuSchool of Health, Leeds Beckett University, Leeds, UK.
Tom R HillHuman Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Ashley AdamsonHuman Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Mario SiervoSchool of Life Sciences, Queen's Medical Centre, The University of Nottingham Medical School, Nottingham, UK.
Anne Marie MinihaneNutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK.
Graciela Muniz-TererraEdinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Craig RitchieEdinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
John C MathersHuman Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK. John.Mathers@Newcastle.ac.uk.
David J Llewellyn *College of Medicine and Health, University of Exeter, Exeter, UK.
Emma Stevenson *Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Newcastle University · GBDeakin University · AULeeds Beckett University · GBUniversity of Edinburgh · GBOhio University · USÖrebro University · SEQueen's University Belfast · GBThe Alan Turing Institute · GBUniversity of Cambridge · GBUniversity of East Anglia · GBUniversity of Exeter · GBUniversity of Nottingham · GB

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council MR/T001852/1
6 · The paper itself

Abstract

backgroundThe identification of effective dementia prevention strategies is a major public health priority, due to the enormous and growing societal cost of this condition. Consumption of a Mediterranean diet (MedDiet) has been proposed to reduce dementia risk. However, current evidence is inconclusive and is typically derived from small cohorts with limited dementia cases. Additionally, few studies have explored the interaction between diet and genetic risk of dementia.

methodsWe used Cox proportional hazard regression models to explore the associations between MedDiet adherence, defined using two different scores (Mediterranean Diet Adherence Screener [MEDAS] continuous and Mediterranean diet Pyramid [PYRAMID] scores), and incident all-cause dementia risk in 60,298 participants from UK Biobank, followed for an average 9.1 years. The interaction between diet and polygenic risk for dementia was also tested.

resultsHigher MedDiet adherence was associated with lower dementia risk (MEDAS continuous: HR = 0.77, 95% CI = 0.65-0.91; PYRAMID: HR = 0.86, 95% CI = 0.73-1.02 for highest versus lowest tertiles). There was no significant interaction between MedDiet adherence defined by the MEDAS continuous and PYRAMID scores and polygenic risk for dementia.

conclusionsHigher adherence to a MedDiet was associated with lower dementia risk, independent of genetic risk, underlining the importance of diet in dementia prevention interventions.

Indexed as

DementiaDiet, MediterraneanBiological Specimen BanksGenetic Predisposition to DiseaseHumansProspective StudiesUnited KingdomAlzheimer’sDementiaGeneticsMediterranean dietPolygenic riskRisk factorsUK Biobank

Identifiers

PMID36915130
PMCPMC10012551
OpenAlexW4324029343

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read153
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.