Evidence map›Paper›PMID 36917681›Full record

Trial reportBrain and behavior2023

Autologous fat grafting to the paravertebral space seems to prevent the postherpetic neuralgia-A single-arm pilot study.

Xiujuan Li, Ran Tao, Xiaoyan Meng, Li Sun, Han Wang, Yuanyuan Sun, Hongda Bi, Yuanchang Xiong

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiujuan LiDepartment of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Ran TaoDepartment of Plastic Surgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Xiaoyan MengDepartment of Critical Care Medicine, Eastern Hepatobiliary Surgery Hospital, Navel Medical University, Shanghai, China.
Li SunDepartment of Anesthesiology and Pain Center, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Han WangDepartment of Anesthesiology and Pain Center, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Yuanyuan SunDepartment of Anesthesiology and Pain Center, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Hongda BiDepartment of Plastic Surgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Yuanchang XiongDepartment of Anesthesiology and Pain Center, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.ORCID 0000-0002-4349-347X
Second Military Medical University · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPostherpetic neuralgia (PHN) is one of the most common complications of Herpes zoster (HZ), yet the mechanism and the treatment for PHN remains elusive. We first performed this feasibility study to verify the safety and efficiency of autologous fat grafting into the paravertebral space in early HZ to prevent PHN.

methodsPatients suffering from HZ with a rash in chest, back, or abdomen were arranged for autologous fat grafting to the paravertebral space. The primary endpoint was the incidence of PHN, which was defined as persistence pain in the affected dermal area in 12 weeks after fat grafting. Secondary endpoints including patient-reported changes in pain intensity, assessed pain threshold and the quality of life during follow-ups.

resultsEight patients accept the intervention and completed all follow-ups. Most patients report immediate pain relief after injection, one patient has a mild to moderate dizzy symptom after injection. No other short- or long-term adverse events occurred. For primary outcome, all patients have a timely reduced pain intensity, with no PHN events occurred, as all patients report pain intensity ≤3 in the VAS scale in 3 months after treatment. For electrical pain threshold, we identify that fat grafting differentially increases sensation and pain threshold in HZ area and healthy skin of patients. Besides, our results indicate significant improvement in patients' life quality decrease in analgesic consumption. DISCUSSION: Autologous fat transplantation to the paravertebral space is a safe and feasible technique in preventing PHN from HZ in a rash. Further randomized controlled trial to investigate the actual long-term benefice of autologous fat grafting to the paravertebral space in preventing PHN is needed.

trial registrationChiCTR, (ChiCTR1900025416); registered August 26, 2019.

Indexed as

ExanthemaHerpes ZosterNeuralgia, PostherpeticAdipose TissueHumansPilot ProjectsQuality of Lifeautologous fat graftingherpes zosterparavertebral spacepilot studypostherpetic neuralgia

Identifiers

PMID36917681
PMCPMC10097047
OpenAlexW4324133073

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.