ArticleNature communications2023
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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11citing papers in PubMed, 1 pooled it
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex hormones and reproductive factors with cardiac arrhythmia and ECG indices: a mendelian randomization study.BMC cardiovascular disorders · 2024Pooled it
- Human genetics across levels of biological organization.Nature reviews. Genetics · 2026Review
- A self-supervised electrocardiogram foundation model for empowering cardiovascular disease prediction and genetic factor discovery.Nature communications · 2026Article
- Empowering genetic discoveries and cardiovascular risk assessment by predicting electrocardiograms from genotype.NPJ digital medicine · 2026Article
- Exploring genetic diversity in genome-wide association studies and polygenic risk scores in the admixed Brazilian population.Genetics and molecular biology · 2026Article
- Extracting Genetically-Imputed Causal Features From ECG Data.Statistical analysis and data mining · 2025Article
- Genomic and molecular evidence that the LncRNA DSP-AS1 modulates desmoplakin expression.Human genetics · 2025Article
- Applying multimodal AI to physiological waveforms improves genetic prediction of cardiovascular traits.American journal of human genetics · 2025Article
- The impact of common and rare genetic variants on bradyarrhythmia development.Nature genetics · 2025Article
- Electrical Heterogeneity in Hispanic Background Subpopulations: The HCHS/SOL.JACC. Advances · 2024Article
- Latent profiles of global electrical heterogeneity: the Hispanic Community Health Study/Study of Latinos.European heart journal. Digital health · 2024Article
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Authors and funding
94 authors.
William J YoungWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.ORCID 0000-0002-9831-6817
Jeffrey HaesslerPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Jan-Walter BenjaminsUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.ORCID 0000-0002-5701-0539
Linda RepettoCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.
Jie YaoInstitute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Aaron IsaacsDept. of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.ORCID 0000-0001-5037-4834
Andrew R HarperRadcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.ORCID 0000-0001-5327-0328
Julia RamirezWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.ORCID 0000-0003-4130-5866
Sophie GarnierSorbonne Universite, INSERM, UMR-S1166, Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics & Pathophysiology of Cardiovascular Disease, Paris, 75013, France.ORCID 0000-0002-7492-1617
Stefan van DuijvenbodenWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.
Antoine R BaldassariDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Maria Pina ConcasInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.ORCID 0000-0003-3598-2537
ThuyVy DuongMcKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Luisa FocoEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.ORCID 0000-0002-6694-3322
Jonas L IsaksenLaboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3227-1131
Hao MeiDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
Raymond NoordamDepartment of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0001-7801-809X
Casia NursyifaNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Anne RichmondMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.
Meddly L SantolallaDepartment of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Negin SoroushDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID 0000-0003-3110-9896
Sébastien ThériaultPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Stella TrompetDepartment of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0001-5006-0528
Stefanie AeschbacherCardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Fariba AhmadizarDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0000-0002-2225-8323
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8509-148X
Archie CampbellUsher Institute, University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, UK.ORCID 0000-0003-0198-5078
Adolfo CorreaDepartments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0002-9501-600X
Dawood DarbarDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USA.ORCID 0000-0002-4103-5977
Antonio De LucaCardiothoracovascular Department, Division of Cardiology, Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste, Trieste, Italy.
Jean-François DeleuzeUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France.ORCID 0000-0002-5358-4463
Christina EllervikDepartment of Data and Data Support, Region Zealand, 4180, Sorø, Denmark.ORCID 0000-0002-3088-4375
Christian FuchsbergerEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.ORCID 0000-0002-5918-8947
Anuj GoelRadcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.ORCID 0000-0003-2307-4021
Christopher GraceRadcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0002-5264-5068
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8748-3831
Susan R HeckbertCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7100-512X
Rebecca D JacksonCenter for Clinical and Translational Science, Ohio State Medical Center, Columbus, OH, USA.
Jan A KorsDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, the Netherlands.
Maria Fernanda Lima-CostaInstituto René Rachou, fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
Allan LinnebergCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, København, Denmark.ORCID 0000-0002-0994-0184
Peter W MacfarlaneInstitute of Health and Wellbeing, School of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0002-5390-1596
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-6381-4296
Pau NavarroMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.ORCID 0000-0001-5576-8584
David J PorteousCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0000-0003-1249-6106
Peter P PramstallerEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.ORCID 0000-0002-9831-8302
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1427-4470
Lorenz RischLabormedizinisches zentrum Dr. Risch, Vaduz, Liechtenstein.ORCID 0000-0003-2692-6699
Ulrich SchottenDept. of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.
Xia ShenCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.ORCID 0000-0003-4390-1979
Gianfranco SinagraCardiothoracovascular Department, Division of Cardiology, Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste, Trieste, Italy.ORCID 0000-0003-2700-8478
Elsayed Z SolimanEpidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston Salem, NC, USA.ORCID 0000-0001-5632-8150
Monika StollMaastricht Center for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands.
Eduardo Tarazona-SantosDepartment of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Andrew TinkerWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.ORCID 0000-0001-7703-4151
Katerina TrajanoskaDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Eric VillardSorbonne Universite, INSERM, UMR-S1166, Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics & Pathophysiology of Cardiovascular Disease, Paris, 75013, France.
Helen R WarrenWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.ORCID 0000-0003-0511-1386
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-4843-3641
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2749-1279
Dan E ArkingMcKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christy L AveryDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-1044-8162
David ConenPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Giorgia GirottoInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.ORCID 0000-0003-4507-6589
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5526-1070
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0000-0002-9405-9550
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-3246-8359
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands, Leiden, the Netherlands.
Morten Salling OlesenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-9477-5322
Sandosh PadmanabhanInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7278-2190
Cristian PattaroEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.ORCID 0000-0002-4119-0109
Antonio Luiz P RibeiroDepartment of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil, Belo Horizonte, Minas Gerais, Brazil.ORCID 0000-0002-2740-0042
Jerome I RotterInstitute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Bruno H StrickerDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Pim van der HarstUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
Cornelia M van DuijnNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-2374-9204
Niek VerweijUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.ORCID 0000-0002-4303-7685
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Michele OriniBarts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK.ORCID 0000-0001-5773-0344
Philippe CharronSorbonne Universite, INSERM, UMR-S1166, Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics & Pathophysiology of Cardiovascular Disease, Paris, 75013, France.ORCID 0000-0002-1782-1118
Hugh WatkinsRadcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.ORCID 0000-0002-5287-9016
Charles KooperbergPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-7986-8560
Henry J LinInstitute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0001-6771-0486
James F WilsonCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.ORCID 0000-0001-5751-9178
Jørgen K KantersLaboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3267-4910
Nona SotoodehniaCardiovascular Health Research Unit, Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Borbala MifsudWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.ORCID 0000-0003-3429-3094
Pier D LambiaseBarts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK.
Larisa G TereshchenkoDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. tereshl@ccf.org.ORCID 0000-0002-6976-1313
Patricia B MunroeWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.ORCID 0000-0002-4176-2947
Funding
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MPeru Infectious Diseases Epidemiology Research Training ConsortiumD43TW007393 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI Andres G Lescano · 2005 to 2026
$5.9MCharacterizing pleiotropy in cardiometabolic phenotypes among diverse populations - Admin SupplR01HL142825 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH · 2019 to 2023
$3.3MDeciphering the genetic mechanisms of atrial fibrillationR01HL138737 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DARBAR, DAWOOD · 2017 to 2020
$2.6MTraining Program in Personalized Cardiovascular Medicine (TPIPCVM)T32HL139439 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DARBAR, DAWOOD · 2018 to 2022
$2.1MNovel ECG Measures and Risk of Sudden Cardiac DeathR01HL118277 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TERESHCHENKO, LARISA GENNADIEVNA · 2013 to 2016
$1.5MSystems Biology Analysis of Cardiac Electrical Activity and Arrhythmias.R01HL141989 · NHLBI · UNIVERSITY OF WASHINGTON · PI ARKING, DAN E, SHOJAIE, ALI · 2019 to 2020
$968kMentoring in patient-oriented atrial fibrillation and cardiovascular researchK24HL148521 · NHLBI · EMORY UNIVERSITY · PI ALONSO, ALVARO · 2019 to 2023
$593kNovel ECG measures and risk of sudden cardiac deathR56HL118277 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TERESHCHENKO, LARISA GENNADIEVNA · 2018 to 2018
$396kBritish Heart Foundation CH/1992001/6764FIC NIH HHS D43 TW007393Medical Research Council MC_PC_20029Medical Research Council MC_UU_00007/10Medical Research Council MR/N025083/1Medical Research Council MR/R017468/1NHLBI NIH HHS K24 HL148521NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL118277NHLBI NIH HHS R01 HL138737NHLBI NIH HHS R01 HL141989NHLBI NIH HHS R01 HL142825NHLBI NIH HHS R56 HL118277NHLBI NIH HHS T32 HL139439
Abstract
The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.
Indexed as
Atrioventricular BlockCardiovascular DiseasesArrhythmias, CardiacBiomarkersElectrocardiographyGenome-Wide Association StudyHumansRisk FactorsBiomarkers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.