Evidence map›Paper›PMID 36919265›Full record

ArticleEndocrinology, diabetes & metabolism2023

Evaluation of serum levels of Irisin as a marker of endothelial dysfunction in patients with type 2 diabetes mellitus.

Thoraya Mohamed Ahmed, Mahmoud Nassar, Hanaa Ahmed Abdallah Mohamed, Khaled El-Sayed Elhadidy, Hanan Mohamed Farhan, Ahmed Sayed Abd El Basset, Riem M Elmessiery, Mahmoud Farid Kamel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, diabetes & metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Thoraya Mohamed AhmedInternal Medicine Department at Faculty of Medicine, Beni Suef University, Beni Suef, Egypt.
Mahmoud NassarInternal Medicine Department at Icahn School of Medicine at Mount Sinai, NYC Health+Hospitals, Queens, New York, USA.ORCID 0000-0002-5401-9562
Hanaa Ahmed Abdallah MohamedInternal Medicine Department at Faculty of Medicine, Beni Suef University, Beni Suef, Egypt.
Khaled El-Sayed ElhadidyInternal Medicine Department at Faculty of Medicine, Beni Suef University, Beni Suef, Egypt.
Hanan Mohamed FarhanClinical and Chemical Pathology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt.
Ahmed Sayed Abd El BassetRadiology Department, Faculty of Medicine, Bani-Suef University, Beni Suef, Egypt.
Riem M ElmessieryInternal Medicine Department, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Mahmoud Farid KamelInternal Medicine Department at Faculty of Medicine, Beni Suef University, Beni Suef, Egypt.
Beni-Suef University · EGCairo University · EGQueens Hospital Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInsulin resistance and obesity have been associated with irisin, a protein in fat cells. The levels of irisin in patients with type 2 diabetes mellitus (T2DM) were significantly lower than those in non-diabetics. This study aimed to examine the relationship between serum irisin levels and endothelial dysfunction in patients with T2DM.

methodsThere were 90 participants in this study. We matched 65 patients with T2DM with 25 healthy control participants. A series of tests were performed on the participants, including fasting blood glucose, 2 hours postprandial blood glucose, glycated haemoglobin, triglycerides (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), TG/HDL-C ratio and albumin/creatinine ratio. In addition to measuring high-sensitivity C-reactive protein (hs-CRP). Enzyme-linked immunosorbent assay (ELISA) technique was used for estimating irisin concentrations.

resultsFlow-mediated dilation (FMD) was significantly lower in patients with T2DM; however, there was a non-statistically significant difference between healthy controls and patients with T2DM regarding serum Irisin level. CRP and LDL levels were inversely correlated with circulating irisin levels. In a stepwise regression analysis, only the hs-CRP and LDL were statistically significant in predicting irisin level.

conclusionsIn patients with T2DM, serum levels of irisin were inversely correlated with hyperglycaemia, body mass index and per cent body fat; this suggests that detecting irisin levels early can prevent cardiovascular diseases from progressing. According to the study results, serum irisin serves as a predictive marker for early cardiovascular disease, thus preventing the disease from progressing. There is a need for further research in order to understand how irisin contributes to the development of atherosclerosis and the development of diabetic complications.

Indexed as

Diabetes Mellitus, Type 2Blood GlucoseCholesterol, HDLC-Reactive ProteinFibronectinsHumansTriglyceridesBlood GlucoseCholesterol, HDLC-Reactive ProteinFibronectinsTriglyceridesinflammationinsulin resistanceIrisinobesityT2DM

Identifiers

PMID36919265
PMCPMC10164434
OpenAlexW4324311113

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.