Evidence map›Paper›PMID 36919441›Full record

ArticleHospital pediatrics2023

Parental Perceptions of Penicillin Allergy Risk Stratification and Delabeling.

James W Antoon, Carlos G Grijalva, Alison R Carroll, Jakobi Johnson, Justine Stassun, Kemberlee Bonnet, David G Schlundt, Derek J Williams

Abstract read
In one paragraph

Article in Hospital pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Penicillin allergy delabeling in long-term care facilities: if not now, then when?Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

James W AntoonDivision of Hospital Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt and Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.
Carlos G GrijalvaDepartments of Health Policy and Bioinformatics, Vanderbilt University Medical Center, Nashville, Tennessee.
Alison R CarrollDivision of Hospital Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt and Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.
Jakobi JohnsonDivision of Hospital Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt and Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.
Justine StassunDivision of Hospital Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt and Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.
Kemberlee BonnetDepartment of Psychology, Vanderbilt University, Nashville, Tennessee.
David G SchlundtDepartment of Psychology, Vanderbilt University, Nashville, Tennessee.
Derek J WilliamsDivision of Hospital Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt and Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Learning Health System training program: PROgRESS--Patient/ pRactice Outcomes and Research in Effectiveness and Systems ScienceT32HS026122 · AHRQ · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRIJALVA, CARLOS G, ROUMIE, CHRISTIANNE L. · 2018 to 2024
$3.5M
Risk Stratification and Decision Support to Improve Care and Outcomes in Children with PneumoniaR01AI125642 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILLIAMS, DEREK J. · 2017 to 2021
$3.3M
Vanderbilt Scholars in T4 Translational Research (V-STTaR) ProgramK12HL137943 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KRIPALANI, SUNIL, ROUMIE, CHRISTIANNE L. · 2017 to 2021
$2.9M
Mentoring in transmission of influenza and strategies for preventionK24AI148459 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRIJALVA, CARLOS G · 2020 to 2024
$893k
Oseltamivir Use and Risk of Serious Neuropsychiatric Adverse Events in ChildrenK23AI168496 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ANTOON, JAMES W · 2022 to 2025
$740k
AHRQ HHS T32 HS026122NCATS NIH HHS UL1 TR002243NHLBI NIH HHS K12 HL137943NIAID NIH HHS K23 AI168496NIAID NIH HHS K24 AI148459NIAID NIH HHS R01 AI125642
6 · The paper itself

Abstract

backgroundPenicillin (PCN) allergy labels are widely recognized to be highly inaccurate. Little is known about parental perceptions of the PCN allergy evaluation and removal process, especially in the hospital setting.

methodsFocus groups were held with parents of children and adolescents with a PCN allergy label discharged from a large academic children's hospital between January 1, 2019, and April 15, 2020. The open-ended, semistructured moderator guide included questions about PCN allergy testing and evaluation, accuracy of the PCN allergy diagnosis, amoxicillin oral challenges, delabeling process, and preferred setting for PCN allergy delabeling evaluation (outpatient clinic, hospital, etc). Study investigators coded the transcripts and identified underlying themes using inductive and deductive thematic analysis.

resultsA total of 21 parents and 2 adolescents participated across 4 focus groups. We developed a theoretical framework depicting key elements of parents' and adolescents' experiences with PCN allergies, consisting of 4 major interconnected themes: (1) family context; (2) the invitation to delabel; (3) decision context; and (4) the PCN delabeling outcome. PCN allergies remained a concern for families even if their children passed an oral challenge. Some parents preferred testing to be performed in the hospital and felt this was a safer location for the procedure.

conclusionsParents are amenable to hospital based PCN allergy evaluation and delabeling. Further studies should incorporate parental and patient preferences to implement safe and effective PCN allergy delabeling processes in the hospital setting.

Indexed as

Drug HypersensitivityHypersensitivityAdolescentAmoxicillinAnti-Bacterial AgentsChildHumansPenicillinsRisk AssessmentAmoxicillinAnti-Bacterial AgentsPenicillins

Identifiers

PMID36919441
PMCPMC10071421

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.