Evidence map›Paper›PMID 36920149›Full record

ArticleJournal of the American Society for Mass Spectrometry2023

Investigation of 2-Hydroxypropyl-β-Cyclodextrin Treatment in a Neuronal-Like Cell Model of Niemann-Pick Type C Using Quantitative Proteomics.

Antony Cougnoux, Melissa R Pergande, Fidel Serna-Perez, Stephanie M Cologna

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Alterations in Proteostasis Mechanisms in Niemann-Pick Type C Disease.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Antony CougnouxDepartment of Cell and Molecular Biology, Karolinska Institutet and Science for Life Laboratory, Solna 171 65, Sweden.
Melissa R PergandeDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Fidel Serna-PerezDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Stephanie M ColognaDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0002-3541-3361
University of Illinois Chicago · USScience for Life Laboratory · SE

Funding

Novel Therapeutic Approaches for NPC DiseaseR01NS124784 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Vinay Aakalu, Stephanie M Cologna · 2022 to 2026
$2.9M
Development of autophagy modulators for evaluation as a therapeutic strategy for Niemann-Pick Type CR01NS114413 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI COLOGNA, STEPHANIE M · 2020 to 2024
$2.0M
NINDS NIH HHS R01 NS114413NINDS NIH HHS R01 NS124784
6 · The paper itself

Abstract

Niemann-Pick, type C (NPC) is a fatal, neurovisceral lysosomal storage disorder with progressive neurodegeneration and no FDA-approved therapy. Significant efforts have been focused on the development of therapeutic options, and 2-hydroxypropyl-β-cyclodextrin (HP-

Indexed as

beta-CyclodextrinsNeuroblastomaNiemann-Pick Disease, Type C2-Hydroxypropyl-beta-cyclodextrinAnimalsCholesterolHumansNeuronsProteomics2-Hydroxypropyl-beta-cyclodextrinbeta-CyclodextrinsCholesterol

Identifiers

PMID36920149
PMCPMC12102752
OpenAlexW4324309670

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.