Evidence map›Paper›PMID 36922503›Full record

ArticleScientific reports2023

Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model.

Ayako Fukunaka, Mari Shimura, Takayuki Ichinose, Ofejiro B Pereye, Yuko Nakagawa, Yasuko Tamura, Wakana Mizutani, Ryota Inoue, Takato Inoue, Yuto Tanaka and 9 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 1 country.

Ayako Fukunaka *Laboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan. fukunaka@gunma-u.ac.jp.
Mari Shimura *Department of Refractory Viral Infection, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. mshimura@ri.ncgm.go.jp.
Takayuki IchinoseInorganic Analysis Laboratories, Toray Research Center, Inc., Otsu, Shiga, Japan.
Ofejiro B PereyeLaboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Yuko NakagawaLaboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Yasuko TamuraLaboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Wakana MizutaniLaboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Ryota InoueLaboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Takato InoueDepartment of Materials Physics, Nagoya University, Nagoya, Japan.
Yuto TanakaGraduate School of Engineering, Osaka University, Osaka, Japan.
Takashi SatoLaboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Tatsuya SaitohLaboratory of Bio-Response Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Toshiyuki FukadaFaculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
Yuya NishidaDepartment of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Takeshi MiyatsukaDepartment of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Jun ShirakawaLaboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Hirotaka WatadaDepartment of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Satoshi MatsuyamaRIKEN SPring-8 Center, Kouto, Hyogo, Japan.
Yoshio FujitaniLaboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan. fujitani@gunma-u.ac.jp.
Gunma University · JPJuntendo University · JPOsaka University · JPNagoya University · JPNational Center for Global Health and Medicine · JPSPring-8 · JPTokushima Bunri University · JPToray Industries, Inc. (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal homeostasis is tightly regulated in cells and organisms, and its disturbance is frequently observed in some diseases such as neurodegenerative diseases and metabolic disorders. Previous studies suggest that zinc and iron are necessary for the normal functions of pancreatic β cells. However, the distribution of elements in normal conditions and the pathophysiological significance of dysregulated elements in the islet in diabetic conditions have remained unclear. In this study, to investigate the dynamics of elements in the pancreatic islets of a diabetic mouse model expressing human islet amyloid polypeptide (hIAPP): hIAPP transgenic (hIAPP-Tg) mice, we performed imaging analysis of elements using synchrotron scanning X-ray fluorescence microscopy and quantitative analysis of elements using inductively coupled plasma mass spectrometry. We found that in the islets, zinc significantly decreased in the early stage of diabetes, while iron gradually decreased concurrently with the increase in blood glucose levels of hIAPP-Tg mice. Notably, when zinc and/or iron were decreased in the islets of hIAPP-Tg mice, dysregulation of glucose-stimulated mitochondrial respiration was observed. Our findings may contribute to clarifying the roles of zinc and iron in islet functions under pathophysiological diabetic conditions.

Indexed as

Diabetes Mellitus, Type 2Insulin-Secreting CellsIslets of LangerhansAmyloidAnimalsHumansIronIslet Amyloid PolypeptideMiceMice, TransgenicZincAmyloidIronIslet Amyloid PolypeptideZinc

Identifiers

PMID36922503
PMCPMC10017767
OpenAlexW4327675616

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read28
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.