SynthesisLipids in health and disease2023
Lipid accumulation product (LAP) index for the diagnosis of nonalcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis.
Synthesis in Lipids in health and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of body roundness index for the prediction of nonalcoholic fatty liver disease: a systematic review and meta-analysis.Lipids in health and disease · 2025Pooled it
- Timing of first abdominal operation in Crohn's disease based on a diagnostic model.Scientific reports · 2024Trial
- Lipid accumulation product (LAP): a key indicator for metabolic dysregulation and inflammatory status in obesity.Scientific reports · 2026Article
- The Value of Five Novel Anthropometric Indicators in Evaluating MASLD and Liver Fibrosis in MASLD: A Cross-Sectional Study.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Comparative Diagnostic Performance of Metabolic Scoring Indices for Ultrasonographic Hepatic Steatosis: Development and Validation of a Novel Composite Score in 1204 Consecutive Patients.Journal of clinical medicine · 2026Article
- The association between visceral fat indices and diabetic peripheral neuropathy in type 2 diabetes mellitus: A retrospective cross-sectional study.Turkish journal of physical medicine and rehabilitation · 2026Article
- Article
- Genome-wide investigations of the lipid accumulation product index pinpoints polygenic determinants underlying pancreatitis susceptibility.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Article
- Associations Between Dietary Diversity Score and Adiposity Indexes in Obese AdolescentsJournal of clinical research in pediatric endocrinology · 2026Article
- Triglyceride-Related Indices and Risk of Acute Pancreatitis: A Prospective Study in UK Biobank.The Kaohsiung journal of medical sciences · 2026Article
- Article
- Adherence to the Mediterranean diet, particularly olive oil intake, and metabolic health parameters are independently associated with SARS-CoV-2 vaccine-induced IgG responses.Metabolism open · 2026Article
- Association between six anthropometric indexes and kidney stones: a population-based cross-sectional study.Translational andrology and urology · 2026Article
- Article
- Comparison of diagnostic value of abdominal obesity and metabolism-related indicators for non-alcoholic fatty liver disease in lean individuals.BMC gastroenterology · 2026Article
- Effect of Qingre Lishi decoction on anthropometric and metabolic risk indices in obese patients with newly diagnosed T2DM: a real-world observational study.Frontiers in endocrinology · 2026Observational
- Comparison of the association and discriminatory ability of CVAI, LAP, CI, and AVI for type 2 diabetes in Chinese adults aged ≥ 50 years: a sex-specific analysis.Frontiers in endocrinology · 2026Article
- When Obesity Hits the Kidneys: Sex-Specific Effects of Visceral Adiposity Indices on Diabetic Kidney Disease Risk.Journal of nutrition and metabolism · 2026Article
- Evaluating the Role of Lipid Accumulation Product Index in Endometriosis: Findings from NHANES and Mendelian Randomization.International journal of women's health · 2026Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLipid accumulation product (LAP) is an index calculated by waist circumference (WC) and triglyceride (TG), which reflects lipid toxicity. This study aims to investigate the association between the LAP index and nonalcoholic fatty liver disease (NAFLD) in a systematic review and meta-analysis. METHODS AND
resultsPubMed, Scopus, and Web of Science online databases were searched for eligible studies that investigated the association of the LAP index and NAFLD. Sixteen observational studies with 96,101 participants, including four cohort studies, one case‒control study and 11 cross-sectional studies with baseline data, were entered into this analysis. Fourteen studies reported a significant association between the LAP index and NAFLD, and two reported that this relation was not significant; two different meta-analyses (1- mean difference (MD) and 2- bivariate diagnostic test accuracy [DTA]) were conducted using Stata version 14. The LAP index was compared in subjects with and without NAFLD, and the difference was significant with 34.90 units (CI 95: 30.59-39.31, P < 0.001) of the LAP index. The DTA meta-analysis was conducted and showed that the LAP index pooled sensitivity and specificity for screening of NAFLD were 94% (CI95: 72%-99%, I
conclusionThe LAP Index is an inexpensive, sensitive, and specific method to evaluate NAFLD and may be valuable for NAFLD screening.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.