Evidence map›Paper›PMID 36922816›Full record

ArticleJournal of nanobiotechnology2023

Combination therapy with ultrasound and 2D nanomaterials promotes recovery after spinal cord injury via Piezo1 downregulation.

Feng Zhang, Xiaolie He, Kun Dong, Li Yang, Bei Ma, Yuchen Liu, Zhibo Liu, Bairu Chen, Rongrong Zhu, Liming Cheng

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Review
  6. Review
  7. The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor.Apoptosis : an international journal on programmed cell death · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. (Ba,Ca)(Ti,Sn)OFrontiers in cellular neuroscience · 2026
    Article
  12. Review
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  14. Review
  15. Review
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  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Feng Zhang *Department of Orthopaedics, School of Medicine, Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, 200065, China.
Xiaolie He *Department of Orthopaedics, School of Medicine, Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, 200065, China.
Kun DongDepartment of Orthopaedics, School of Medicine, Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, 200065, China.
Li YangDepartment of Orthopaedics, School of Medicine, Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, 200065, China.
Bei MaDepartment of Orthopaedics, School of Medicine, Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, 200065, China.
Yuchen LiuDepartment of Orthopaedics, School of Medicine, Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, 200065, China.
Zhibo LiuDepartment of Orthopaedics, School of Medicine, Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, 200065, China.
Bairu ChenDepartment of Orthopaedics, School of Medicine, Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, 200065, China.
Rongrong ZhuDepartment of Orthopaedics, School of Medicine, Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, 200065, China. rrzhu@tongji.edu.cn.
Liming ChengDepartment of Orthopaedics, School of Medicine, Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, 200065, China. limingcheng@tongji.edu.cn.
Tongji University · CNTongji Hospital · CN

Funding

Basic Research Project of Shanghai Science and Technology Commission 19JC1414700China Postdoctoral Science Foundation 2021M692430National Key Research and Development Program of China 2021YFA1101301National Natural Science Foundation of China 31727801National Natural Science Foundation of China 82225027
6 · The paper itself

Abstract

Spinal cord injury (SCI) causes severe neurological dysfunction and currently has no effective treatment. Due to the complex pathophysiological processes associated with SCI and the limited efficacy of single strategies, the need for combined strategies for effective SCI therapy is becoming increasingly apparent. In this study, we evaluated the combined effects of layered double hydroxide-coupled NT3 (MgFe-LDH/NT3) nanoparticles (NPs) and ultrasound (US) both in vitro and in vivo. Combined treatment promoted neural stem cell (NSC) differentiation into neurons and exerted anti-inflammatory effects in vitro. Furthermore, combined therapy promoted behavioural and electrophysiological performance at eight weeks in a completely transected murine thoracic SCI model. Additional RNA sequencing revealed that ultrasonic-induced Piezo1 downregulation is the core mechanism by which combined therapy promotes neurogenesis and inhibits inflammation, and the Piezo1/NF-κB pathways were identified. Hence, the findings of this study demonstrated that the combination of ultrasound and functional NPs may be a promising novel strategy for repairing SCI.

Indexed as

NanostructuresNeural Stem CellsSpinal Cord InjuriesAnimalsDown-RegulationIon ChannelsMiceRatsRats, Sprague-DawleyIon ChannelsPiezo1 protein, mouseInflammationNanoparticlesPiezo1Spinal cord injuryUltrasound

Identifiers

PMID36922816
PMCPMC10018903
OpenAlexW4327686656

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read55
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.