SynthesisFrontiers in immunology2023
Association of normal weight obesity phenotype with inflammatory markers: A systematic review and meta-analysis.
Synthesis in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Malnutrition in Obesity: When BMI-Based Screening Masks Clinical Risk.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Associations of obesity phenotypes with incident fall rates: results from the objective physical activity and cardiovascular disease health in older women study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Children born small-for-gestational-age exhibit normal body fat but elevated hs-CRP and hepatocellular lipid content.Pediatric research · 2026Article
- Visceral Adiposity and Markers of Relative Sarcopenia in Young Adults with Normal Weight Obesity: Gender Differences.Healthcare (Basel, Switzerland) · 2026Article
- Hematological markers of proinflammatory and prothrombotic states in normal-weight obesity (NWO).Scientific reports · 2026Article
- Anthocyanin Supplementation and Inflammation: A Systematic Review and Meta-Analysis of IL-8, IL-10, IL-18, IFN-γ, and Resistin in Healthy, Overweight, and Obese Populations.Food science & nutrition · 2026Review
- A study of mental health status and its influencing factors in normal weight obesity population.Scientific reports · 2026Article
- Nutrition and health canteen-based lifestyle intervention: association with weight management, lipid metabolism regulation, and inflammation alleviation in middle-aged adults.Frontiers in nutrition · 2026Article
- Is metabolically healthy obesity shaped by inflammation, gender differences, and fat distribution?World journal of cardiology · 2025Article
- Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation.European journal of clinical investigation · 2025Review
- Normal Weight Obesity Overview and Update: A narrative review.Current obesity reports · 2025Review
- Adolescents with Normal Weight Obesity Have Less Dry Lean Mass Compared to Obese Counterparts.International journal of environmental research and public health · 2025Article
- Association between normal weight obesity and comorbidities and events of cardiovascular diseases among adults in South China.PloS one · 2025Article
- More evidence of the health risks of normal weight obesity: the association with systemic inflammation.Frontiers in medicine · 2025Article
- Association between inflammatory markers, body composition and frailty in home-dwelling elderly: an 8-year follow-up study.GeroScience · 2024Article
- Article
- Normal-Weight Obesity and Metabolic Syndrome in Korean Adults: A Population-Based Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2023Article
- Leptin Concentrations Determine the Association between High-Sensitivity C-Reactive Protein Levels and Body Mass Index in Prepubertal Children.Nutrients · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Individuals with normal weight could suffer from obesity based on their body fat percentage (also known as normal weight obesity (NWO)), thus being at risk of significant morbidity and mortality compared to the general population. It seems that inflammatory pathways and chronic inflammation are significant contributors to the pathogenicity of NWO. This study aimed to assess and pool the association of proinflammatory and anti-inflammatory cytokines with NWO. Methods: In this systematic review and meta-analysis, online international databases (PubMed, Scopus, EMBASE, Web of Science, and Google Scholar) were searched until August 2022. All observational studies with an English full text comparing the mean levels of proinflammatory and anti-inflammatory cytokines (e.g., C-reactive protein (CRP), various types of interleukins (IL) s, tumor necrosis factor-alpha (TNF)) and white blood cell (WBC) count, in subjects with NWO and "normal weight non-obese (NWNO)" were included. Two researchers independently screened, reviewed and assessed the quality of included studies. The remaining articles' data were extracted post-screening. The heterogeneity between studies was assessed using the I Results: From the initial 559 studies, 21 and 19 were included in the qualitative and quantitative synthesis, respectively. In the systematic review, 8 studies reported a significant association between various proinflammatory cytokines (CRP, IL Conclusion: The findings of this study show that NWO was associated with high levels of CRP and IL6. Therefore, inflammatory pathways may play a role in the pathogenicity of NWO.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.