Evidence map›Paper›PMID 36924350›Full record

ArticlePacing and clinical electrophysiology : PACE2023

Association of abnormal p-wave parameters with brain MRI morphology: The atherosclerosis risk in communities neurocognitive study (ARIC-NCS).

Jorge L Reyes, Faye L Norby, Yuekai Ji, Wendy Wang, Romil Parikh, Michael J Zhang, Niki C Oldenburg, Pamela L Lutsey, Clifford R Jack, Michelle Johansen and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pacing and clinical electrophysiology : PACE, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Heart-Brain Axis: Subclinical Cardiovascular Changes and Brain Health.Journal of the American Heart Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Jorge L ReyesLillehei Heart Institute and Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID 0000-0002-9180-0016
Faye L NorbyCenter for Cardiac Arrest Prevention, Department of Cardiology, Cedars-Sinai Smidt Heart Institute, Los Angeles, California, USA.
Yuekai JiLillehei Heart Institute and Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Wendy WangDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-6025-0173
Romil ParikhDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Michael J ZhangLillehei Heart Institute and Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID 0000-0003-2537-2831
Niki C OldenburgDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Pamela L LutseyDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Michelle JohansenDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rebecca F GottesmanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Josef CoreshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Thomas MosleyThe Memory Impairment and Neurodegenerative Dementia Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Elsayed Z SolimanDepartment of Epidemiology, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Lin Yee ChenLillehei Heart Institute and Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
University of Minnesota · USJohns Hopkins University · USCedars-Sinai Smidt Heart Institute · USEmory University · USMayo Clinic · USUniversity of Mississippi Medical Center · USWake Forest University · US

Funding

The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI ALLAN I LEVEY · 2020 to 2026
$29.0M
Cardiovascular Disease Epidemiology &Prevention TrngT32HL007779 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PAMELA L. Lutsey, JAMES S PANKOW · 1994 to 2026
$9.3M
Stroke, Cognition and Neuroepidemiology SectionZIANS009435 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOTTESMAN, REBECCA F · 2022 to 2025
$8.2M
Cognitive Aging, Brain Morphology, and Arrhythmias in Hispanics/Latinos: Implications for Prevention and Management of Alzheimer's Disease-Related DementiasRF1NS127266 · NINDS · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE, GONZALEZ, HECTOR M · 2022 to 2022
$4.1M
Novel application of Digital signals of movement, sleep and heart rhythms for detection of Alzheimer's Disease and Related DementiasR01AG075883 · NIA · JOHNS HOPKINS UNIVERSITY · PI Lin Yee Chen, Ciprian M Crainiceanu · 2022 to 2026
$3.8M
Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling ElderlyR01HL126637 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE · 2016 to 2020
$3.7M
Glucose patterns and cardiac arrhythmias in older adults with diabetesR01HL158022 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CHEN, LIN YEE, SELVIN, ELIZABETH · 2022 to 2025
$2.8M
Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive DeclineR01HL141288 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE · 2018 to 2021
$2.1M
Mentoring and Research to ClassifyAtrial CardiomyopathyK24HL155813 · NHLBI · UNIVERSITY OF MINNESOTA · PI Lin Yee Chen · 2021 to 2026
$770k
Sudden Death Associated with Substance UseK01HL164764 · NHLBI · UNIVERSITY OF MINNESOTA · PI Faye Norby · 2022 to 2026
$706k
Mentoring in patient-oriented atrial fibrillation and cardiovascular researchK24HL148521 · NHLBI · EMORY UNIVERSITY · PI ALONSO, ALVARO · 2019 to 2023
$593k
Arterial Structure and Function and Atrial FibrillationR21AG042660 · NIA · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE · 2013 to 2014
$417k
NHLBI NIH HHS HHSN268201000003CNHLBI NIH HHS HHSN268201000005CNHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS K01 HL164764NHLBI NIH HHS K24 HL148521NHLBI NIH HHS K24HL148521NHLBI NIH HHS K24 HL155813NHLBI NIH HHS R01 HL126637NHLBI NIH HHS R01 HL141288NHLBI NIH HHS R01 HL158022NHLBI NIH HHS T32 HL007779NIA NIH HHS P30 AG066511NIA NIH HHS R01 AG075883NIA NIH HHS R21 AG042660NINDS NIH HHS RF1 NS127266
6 · The paper itself

Abstract

backgroundRecent evidence indicates that abnormal P-wave parameters (PWPs)-ECG markers of atrial myopathy-are associated with incident dementia, independent of atrial fibrillation (AF) and clinical ischemic stroke. However, the mechanisms remain unclear and may include subclinical vascular brain injury. Hence, we evaluated the association of abnormal PWPs with brain MRI correlates of vascular brain injury in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS).

methodsARIC-NCS participants who underwent 3T brain MRI scans in 2011-2013 were included. PWPs were measured from standard 12-lead ECGs. Brain MRI outcomes included cortical infarcts, lacunar infarcts, cerebral microhemorrhages, brain volumes, and white matter disease (WMD) volume. We used weighted multivariable logistic and linear regression to evaluate the associations of abnormal PWPs with brain MRI outcomes.

resultsAmong 1715 participants (mean age, 76.1 years; 61% women; 29% Black), 797 (46%) had ≥1 abnormal PWP. After multivariable adjustment, including adjusting for prevalent AF, abnormal P-wave terminal force in lead V1 (aPTFV1) and prolonged P-wave duration (PPWD) were associated with increased odds of both cortical (OR 1.41; 95% CI, 1.14 to 1.74 and OR 1.30; 95% CI, 1.04 to 1.63, respectively) and lacunar infarcts (OR 1.36; 95% CI, 1.15 to 1.63 and OR 1.37; 95% CI, 1.15 to 1.65, respectively). Advanced interatrial block (aIAB) was associated with higher odds of subcortical microhemorrhage (OR 2.04; 95% CI, 1.36 to 3.06). Other than a significant association between aPTFV1 with lower parietal lobe volume, there were no other significant associations with brain or WMD volume.

conclusionIn this exploratory analysis of a US community-based cohort, ECG surrogates of atrial myopathy are associated with a higher prevalence of brain infarcts and microhemorrhage, suggesting subclinical vascular brain injury as a possible mechanism underlying the association of atrial myopathy with dementia.

Indexed as

AtherosclerosisAtrial FibrillationCerebrovascular TraumaDementiaAgedBrainFemaleHumansMagnetic Resonance ImagingMaleRisk Factorsbrain infarctsmicrohemorrhagesP-waves parameters

Identifiers

PMID36924350
PMCPMC10440299
OpenAlexW4327596380

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.