Evidence map›Paper›PMID 36925929›Full record

ReviewFrontiers in oncology2023

On the importance of interpretable machine learning predictions to inform clinical decision making in oncology.

Sheng-Chieh Lu, Christine L Swisher, Caroline Chung, David Jaffray, Chris Sidey-Gibbons

Open access · goldFull text readReview
In one paragraph

Review in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 2 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. AI in Medical Questionnaires: Scoping ReviewJournal of medical Internet research · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sheng-Chieh LuSection of Patient-Centered Analytics, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Christine L SwisherThe Ronin Project, San Mateo, CA, United States.
Caroline ChungDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
David JaffrayInstitute for Data Science in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Chris Sidey-GibbonsSection of Patient-Centered Analytics, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
The University of Texas MD Anderson Cancer Center · USEllison Institute of Technology

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Machine learning-based tools are capable of guiding individualized clinical management and decision-making by providing predictions of a patient's future health state. Through their ability to model complex nonlinear relationships, ML algorithms can often outperform traditional statistical prediction approaches, but the use of nonlinear functions can mean that ML techniques may also be less interpretable than traditional statistical methodologies. While there are benefits of intrinsic interpretability, many model-agnostic approaches now exist and can provide insight into the way in which ML systems make decisions. In this paper, we describe how different algorithms can be interpreted and introduce some techniques for interpreting complex nonlinear algorithms.

Indexed as

decision-making supporthigh-stakes predictioninterpretability and explainabilityopaque machine learning modelsprecision medicine

Identifiers

PMID36925929
PMCPMC10013157
OpenAlexW4322752859

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read3
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.