ArticleEnvironmental health perspectives2023
Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study.
Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- An Exploration of Machine Learning Methods in Human Biomonitoring.International journal of environmental research and public health · 2026Review
- Micronutrients as Mitigators of Endocrine Disrupting Chemical Health Effects: A Scoping Review and Framework for Epidemiologic Studies.Current environmental health reports · 2026Article
- Maternal environmental exposure and early-life health risks: The modulating role of nutritional status-A scoping review.iScience · 2026Review
- Hepatic AhR Activation by TCDD Induces Obesity and Steatosis via Hepatic Plasminogen Activator Inhibitor-1 (PAI-1).International journal of molecular sciences · 2025Article
- Using mixture and exposome methods to assess the associations and interactions of chemical biomarkers with semen parameters.Environment international · 2025Article
- Hidden link between endocrine-disrupting chemicals and pediatric obesity.Clinical and experimental pediatrics · 2025Article
- Review
- The Need for an Alternative Health Claim Process for Foods Based on Both Nutrient and Contaminant Profiles.Current developments in nutrition · 2024Article
- PFAS: exploration of neurotoxicity and environmental impact.Environmental science and pollution research international · 2024Review
- The Obesity Epidemic Is Not the Victims' Fault.Obesity surgery · 2024Article
- Invited Perspective: Can Eating a Healthy Diet during Pregnancy Attenuate the Obesogenic Effects of Persistent Organic Pollutants?Environmental health perspectives · 2023Article
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrenatal exposure to persistent organic pollutants (POPs) may contribute to the development of childhood obesity and metabolic disorders. However, little is known about whether the maternal nutritional status during pregnancy can modulate these associations.
objectivesThe main objective was to characterize the joint associations and interactions between prenatal levels of POPs and nutrients on childhood obesity.
methodsWe used data from to the Spanish INfancia y Medio Ambiente-Environment and Childhood (INMA) birth cohort, on POPs and nutritional biomarkers measured in maternal blood collected at the first trimester of pregnancy and child anthropometric measurements at 7 years of age. Six organochlorine compounds (OCs) [dichlorodiphenyldichloroethylene, hexachlorobenzene (HCB),
resultsForty percent of children had overweight or obesity. We observed a positive overall joint association of both POPs-nutrients mixtures on overweight/obesity risk, with HCB and vitamin B12 the biomarkers contributing the most. Recurrent interactions were found between HCB and vitamin B12 across screening models. Relative risk for a natural log increase of HCB was 1.31 (95% CI: 1.11, 1.54,
conclusionThese results support that maternal nutritional status may modulate the effect of prenatal exposure to POPs on childhood overweight/obesity. These findings may help to develop a biological hypothesis for future toxicological studies and to better interpret inconsistent findings in epidemiological studies. https://doi.org/10.1289/EHP11258.
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