Evidence map›Paper›PMID 36927424›Full record

ReviewCurrent medicinal chemistry2024

Multiple Natural Polymers in Drug and Gene Delivery Systems.

Zhengfa Jiang, Zongmian Song, Chen Cao, Miaoheng Yan, Zhendong Liu, Xingbo Cheng, Hongbo Wang, Qingnan Wang, Hongjian Liu, Songfeng Chen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Zhengfa JiangDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, PR China.
Zongmian SongDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, PR China.
Chen CaoDepartment of Orthopedics, Zhengzhou University People's Hospital, Zhengzhou, 450003, PR China.
Miaoheng YanDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, PR China.
Zhendong LiuDepartment of Orthopedics, Zhengzhou University People's Hospital, Zhengzhou, 450003, PR China.
Xingbo ChengDepartment of Orthopedics, Zhengzhou University People's Hospital, Zhengzhou, 450003, PR China.
Hongbo WangDepartment of Orthopedics, Zhengzhou University People's Hospital, Zhengzhou, 450003, PR China.
Qingnan WangDepartment of Orthopedics, Zhengzhou University People's Hospital, Zhengzhou, 450003, PR China.
Hongjian LiuDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, PR China.
Songfeng ChenDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, PR China.
First Affiliated Hospital of Zhengzhou University · CNZhengzhou People's Hospital · CNZhengzhou University · CNHenan Provincial People's Hospital · CN

Funding

Henan Province Medical Science and Technology Research Project SBGJ20-2002033Henan Province Middle-aged and Young Health Science and Technology Innovation Outstanding Young Talent Training Project YXKC2021058Henan provincial Science and Technology Research and Development Plan Joint Fund Cutivation Project 222301420048National Natural Science Foundation of China 81902253, 82172484
6 · The paper itself

Abstract

Natural polymers are organic compounds produced by living organisms. In nature, they exist in three main forms, including proteins, polysaccharides, and nucleic acids. In recent years, with the continuous research on drug and gene delivery systems, scholars have found that natural polymers have promising applications in drug and gene delivery systems due to their excellent properties such as biocompatibility, biodegradability, low immunogenicity, and easy modification. However, since the structure, physicochemical properties, pharmacological properties and biological characteristics of biopolymer molecules have not yet been entirely understood, further studies are required before large-scale clinical application. This review focuses on recent advances in the representative natural polymers such as proteins (albumin, collagen, elastin), polysaccharides (chitosan, alginate, cellulose) and nucleic acids. We introduce the characteristics of various types of natural polymers, and further outline the characterization methods and delivery forms of these natural polymers. Finally, we discuss possible challenges for natural polymers in subsequent experimental studies and clinical applications. It provides an important strategy for the clinical application of natural polymers in drug and gene delivery systems.

Indexed as

Gene Transfer TechniquesAnimalsBiological ProductsBiopolymersDrug CarriersDrug Delivery SystemsHumansNucleic AcidsPolymersPolysaccharidesBiological ProductsBiopolymersDrug CarriersNucleic AcidsPolymersPolysaccharidescharacterization methodscontrolled drug releasedelivery forms.drug deliverygene deliveryNatural polymers

Identifiers

PMID36927424
OpenAlexW4327683671

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.