Evidence map›Paper›PMID 36928332›Full record

ArticleTropical animal health and production2023

Genome-wide identification and annotation of SNPs and their mapping in candidate genes related to milk production and fertility traits in Badri cattle.

Javid Ur Rahman, Devendra Kumar, Satya Pal Singh, Bijendra Narayan Shahi, Ashis Kumar Ghosh, Manish Kumar Verma, Abhishek Pathak, Aashaq Hussain Dar, Anil Kumar, Rabendra Kumar Sharma

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Article in Tropical animal health and production, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  7. Polymorphisms ofAnimals : an open access journal from MDPI · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Javid Ur RahmanDapartment of Animal Genetics and Breeding, College of Veterinary & Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India. drjavid763@gmail.com.ORCID http://orcid.org/0000-0002-5190-6019
Devendra KumarDapartment of Animal Genetics and Breeding, College of Veterinary & Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Satya Pal SinghDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary & Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Bijendra Narayan ShahiDapartment of Animal Genetics and Breeding, College of Veterinary & Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Ashis Kumar GhoshDapartment of Animal Genetics and Breeding, College of Veterinary & Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Manish Kumar VermaDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary & Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Abhishek PathakDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary & Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Aashaq Hussain DarDepartment of Livestock Production and Management, College of Veterinary & Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Anil KumarDepartment of Livestock Production and Management, College of Veterinary & Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Rabendra Kumar SharmaDepartment of Livestock Production and Management, College of Veterinary & Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Govind Ballabh Pant University of Agriculture and Technology · IN

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/BI/01/069/2018Indian Council of Agricultural Research 2018Indian Council of Agricultural Research Ag. Edn. 2(9)/2018-HRD dated 30th October
6 · The paper itself

Abstract

This study was conducted in Badri cattle using a double digest restriction-site associated DNA sequencing approach. The study aimed to identify and annotate high confidence single nucleotide polymorphisms (SNPs) and their mapping in candidate genes related to production and fertility in dairy cattle. A total of 7,168,552 genome-wide SNPs were initially identified in Badri cattle by alignment with the Bos indicus reference genome. After filtration of SNPs, 65,483 high confidence SNPs were retained and further used for downstream analysis. Annotation of high confidence SNPs revealed 99.197% SNPs had modifier impact, 0.326% SNPs were low impact, 0.036% were high impact, and 0.441% were moderate impact SNPs. Most SNPs in Badri cattle were found in intergenic, transcript and intronic regions. The candidate genes for milk production PRKCE, ABCG2, GHR, EPS8, CAST and NRXN1 were found to harbour maximum high confidence variants. Among candidate genes for fertility in cattle, ATP2B1, SOX5, WDR27, ARHGAP12, CACNA1D, ANKRD6, GRIA3, ZNF521 and CAST822 have maximum high confidence variants mapped in them. The SNPs found mapped in the candidate genes will be important genetic tools in the search for phenotype-modifying nucleotide changes and will aid in formulating relevant genetic improvement programmes for dairy cattle.

Indexed as

FertilityMilkPolymorphism, Single NucleotideAnimalsCattleGenome-Wide Association StudyLactationPhenotypeAnnotationBos indicusddRAD sequencingFertilityGenesProduction traits

Identifiers

PMID36928332
OpenAlexW4327678679

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.