Evidence map›Paper›PMID 36928640›Full record

ArticleMolecular biology reports2023

Cardiac-specific overexpression of insulin-like growth factor II receptor-α interferes with the regulation of calcium homeostasis in the heart under hyperglycemic conditions.

Shang-Yeh Lu, Bruce Chi-Kang Tsai, Dao Van Thao, Chin-Hu Lai, Michael Yu-Chih Chen, Wei-Wen Kuo, Chia-Hua Kuo, Kuan-Ho Lin, Dennis Jine-Yuan Hsieh, Chih-Yang Huang

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Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Shang-Yeh LuGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Bruce Chi-Kang TsaiCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Dao Van ThaoCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Chin-Hu LaiDivision of Cardiovascular Surgery, Department of Surgery, Taichung Armed Force General Hospital, Taichung, Taiwan.
Michael Yu-Chih ChenDepartment of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Wei-Wen KuoDepartment of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.
Chia-Hua KuoLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Kuan-Ho LinDivision of Cardiovascular Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
Dennis Jine-Yuan Hsieh *School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
Chih-Yang Huang *Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan. cyhuang.tc@gmail.com.ORCID http://orcid.org/0000-0003-2347-0411
China Medical University · TWTzu Chi Foundation · TWAsia University · TWBuddhist Tzu Chi General Hospital · TWChung Shan Medical University Hospital · TWTaichung Armed Forces General Hospital · TWWilliam & Mary · US

Funding

China Medical University (TW) CMU107-TC-03Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation IMAR-109-01-04-01
6 · The paper itself

Abstract

backgroundDiabetic cardiomyopathy is a progressive disease caused by inexplicit mechanisms, and a novel factor, insulin-like growth factor II receptor-α (IGF-IIRα), may contribute to aggravating its pathogenesis. We hypothesized that IGF-IIRα could intensify diabetic heart injury. METHODS AND

resultsTo demonstrate the potential role of IGF-IIRα in the diabetic heart, we used (SD-TG [IGF-IIRα]) transgenic rat model with cardiac-specific overexpression of IGF-IIRα, along with H9c2 cells, to study the effects of IGF-IIRα in the heart under hyperglycemic conditions. IGF-IIRα was found to remodel calcium homeostasis and intracellular Ca

conclusionsOur study reveals the novel role of IGF-IIRα in regulating cardiac intracellular Ca

Indexed as

CalciumDiabetic CardiomyopathiesAnimalsCalcium-Binding ProteinsHeartHomeostasisInsulin-Like Growth Factor IIMyocytes, CardiacRatsRats, TransgenicSarcoplasmic Reticulum Calcium-Transporting ATPasesCalciumCalcium-Binding ProteinsInsulin-Like Growth Factor IISarcoplasmic Reticulum Calcium-Transporting ATPasesAutophagyCalciumDiabetesHeartHyperglycemiaIGF-IIRα

Identifiers

PMID36928640
OpenAlexW4327599151

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.