Evidence map›Paper›PMID 36930640›Full record

ArticleThe Journal of infectious diseases2023

Biotypes of Central Nervous System Complications in People With Human Immunodeficiency Virus: Virology, Immunology, and Neuropathology.

Sarah B Joseph, Sara Gianella, Tricia H Burdo, Paola Cinque, Magnus Gisslen, Scott Letendre, Avindra Nath, Susan Morgello, Lishomwa C Ndhlovu, Serena Spudich

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 3 countries.

Sarah B JosephDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0001-9603-574X
Sara GianellaDepartment of Medicine, Division of Infectious Disease and Global Public Health, University of California, San Diego, La Jolla, California, USA.
Tricia H BurdoDepartment of Microbiology, Immunology and Inflammation, Center for NeuroVirology and Gene Editing, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Paola CinqueUnit of Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy.
Magnus GisslenDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Scott LetendreDepartment of Medicine, Division of Infectious Disease and Global Public Health, University of California, San Diego, La Jolla, California, USA.
Avindra NathNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0003-0927-5855
Susan MorgelloDepartments of Neurology, Neuroscience, and Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Lishomwa C NdhlovuDepartment of Medicine, Division of Infectious Diseases, Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA.
Serena SpudichDepartment of Neurology, Yale School of Medicine, New Haven, Connecticut, USA.
University of California San Diego · USCornell University · USIcahn School of Medicine at Mount Sinai · USNational Institutes of Health · USSahlgrenska University Hospital · SESan Raffaele University of Rome · ITTemple University · USUniversity of North Carolina at Chapel Hill · USYale University · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN JANET LITTLE · 1994 to 2026
$78.4M
Neuropathogenesis of Retroviral InfectionsZIANS003130 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NATH, AVINDRA · 2011 to 2025
$73.7M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jessica Lynette Montoya · 2001 to 2026
$50.4M
HOPE - HIV Obstruction by Programmed EpigeneticsUM1AI164559 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI Lishomwa C Ndhlovu, Melanie Maria Ott · 2021 to 2026
$32.2M
Collaboratory of AIDS Researchers for Eradication (CARE)UM1AI164567 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2021 to 2026
$31.6M
Collaboratory of AIDS Researchers for Eradication (CARE)UM1AI126619 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARGOLIS, DAVID M. · 2016 to 2020
$23.2M
The Y-SCORCH Data Generation Center at Yale for Single-Cell Opioid Responses in the Context of HIVUM1DA051410 · NIDA · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, KLUGER, YUVAL · 2020 to 2025
$15.3M
The Manhattan HIV Brain BankU24MH100931 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORGELLO, SUSAN · 2013 to 2023
$14.0M
CHARTER Plus: A resource for cutting-edge research on neurological function and mental health in people with HIV and substance use disorders across the lifespanR24MH129166 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RONALD J. ELLIS, Scott L Letendre · 2022 to 2026
$9.9M
HOPE Training GrantT32AI007384 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sara Gianella Weibel, Scott L Letendre · 1990 to 2026
$9.7M
CNS Viral Persistence and Neuropsychiatric Perturbations in HIV: Single cell and Molecular InterrogationR01MH125737 · NIMH · YALE UNIVERSITY · PI CYKTOR, JOSHUA CHARLES, SPUDICH, SERENA S · 2021 to 2025
$5.4M
NCATS NIH HHS UL1 TR001442NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI147849NIAID NIH HHS T32 AI007384NIAID NIH HHS UM1 AI126619NIAID NIH HHS UM1 AI164559NIAID NIH HHS UM1 AI164567NIA NIH HHS R01 AG063659NIA NIH HHS R01 AG063846NIDA NIH HHS R01 DA047879NIDA NIH HHS R01 DA050491NIDA NIH HHS R01 DA051890NIDA NIH HHS U01 DA053625NIDA NIH HHS UM1 DA051410NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH106466NIMH NIH HHS R01 MH118990NIMH NIH HHS R01 MH125396NIMH NIH HHS R01 MH125720NIMH NIH HHS R01 MH125737NIMH NIH HHS R21 MH122243NIMH NIH HHS R24 MH129166NIMH NIH HHS R25 MH108389NIMH NIH HHS U24 MH100931NINDS NIH HHS R01 NS117458
6 · The paper itself

Abstract

Despite viral suppression with antiretroviral therapy (ART), people with human immunodeficiency virus (HIV) continue to experience central nervous system (CNS) complications, primarily in the form of mild cognitive impairment and mental health disorders (eg, depression, anxiety, other neuropsychiatric problems). The multifactorial pathogenesis and heterogeneity of mechanisms likely underlying CNS complications must be addressed in the development of preventive interventions and effective treatments. The biotyping approach has previously been useful to define phenotypes of other CNS diseases based on underlying mechanisms and could be translated to the field of neuroHIV. The purpose of the Biotype Workshop series, and the Virology, Immunology and Neuropathology Working Group in particular, is to capitalize on current and new technologies and guide future research efforts using the wealth of available immunological, virologic, and neuropathological data collected from people with HIV on and off ART.

Indexed as

Central Nervous System DiseasesCognitive DysfunctionHIV-1HIV InfectionsCentral Nervous SystemHumansbiomarkersbiotypeHANDHIV-associated cognitive disorderinflammationneuroHIV

Identifiers

PMID36930640
PMCPMC10022721
OpenAlexW4327685877

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.