Evidence mapPaperPMID 36930729Full record

ArticleGenetics2023

2022 updates to the Rat Genome Database: a Findable, Accessible, Interoperable, and Reusable (FAIR) resource.

Mahima Vedi, Jennifer R Smith, G Thomas Hayman, Monika Tutaj, Kent C Brodie, Jeffrey L De Pons, Wendy M Demos, Adam C Gibson, Mary L Kaldunski, Logan Lamers and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Genome-wide association mapping and targeted loss of function studies identifyProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Mahima VediThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-5361-6739
Jennifer R SmithThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-6443-9376
G Thomas HaymanThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-9553-7227
Monika TutajThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-0378-4002
Kent C BrodieClinical and Translational Science Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-9984-3619
Jeffrey L De PonsThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-7783-1556
Wendy M DemosThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-8037-076X
Adam C GibsonThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-8301-6590
Mary L KaldunskiThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0003-3645-6803
Logan LamersThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-9013-7155
Stanley J F LaulederkindThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-5356-4174
Jyothi ThotaThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0003-4482-7627
Ketaki ThoratThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-8288-6671
Marek A TutajThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-1025-101X
Shur-Jen WangThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-5256-8683
Stacy ZacherFinance and Administration, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0003-2524-3829
Melinda R DwinellThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-9528-3618
Anne E KwitekThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0003-1024-4116
Medical College of Wisconsin · US

Funding

RAT GENOME DATABASER01HL064541 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · 1999 to 2025
$19.5M
Alliance Central: A platform for sustainable development of next generation genome knowledgebasesU24HG010859 · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2025 to 2025
$5.2M
NHGRI NIH HHS U24 HG010859NHLBI NIH HHS P01 HL149620NHLBI NIH HHS R01 HL064541
6 · The paper itself

Abstract

The Rat Genome Database (RGD, https://rgd.mcw.edu) has evolved from simply a resource for rat genetic markers, maps, and genes, by adding multiple genomic data types and extensive disease and phenotype annotations and developing tools to effectively mine, analyze, and visualize the available data, to empower investigators in their hypothesis-driven research. Leveraging its robust and flexible infrastructure, RGD has added data for human and eight other model organisms (mouse, 13-lined ground squirrel, chinchilla, naked mole-rat, dog, pig, African green monkey/vervet, and bonobo) besides rat to enhance its translational aspect. This article presents an overview of the database with the most recent additions to RGD's genome, variant, and quantitative phenotype data. We also briefly introduce Virtual Comparative Map (VCMap), an updated tool that explores synteny between species as an improvement to RGD's suite of tools, followed by a discussion regarding the refinements to the existing PhenoMiner tool that assists researchers in finding and comparing quantitative data across rat strains. Collectively, RGD focuses on providing a continuously improving, consistent, and high-quality data resource for researchers while advancing data reproducibility and fulfilling Findable, Accessible, Interoperable, and Reusable (FAIR) data principles.

Indexed as

Databases, GeneticGenomeAnimalsChlorocebus aethiopsDogsGenomicsHumansMiceOligopeptidesReproducibility of ResultsSwineOligopeptidescomparative genomeFAIR datagenomicsquantitative phenotyperat geneticsRat Genome Databaserat strainRattus norvegicus

Identifiers

PMID36930729
PMCPMC10474928
OpenAlexW4327712031

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.