Evidence map›Paper›PMID 36930852›Full record

ArticleAssay and drug development technologies2023

Identification of Potent, Selective, and Peripherally Restricted Serotonin Receptor 2B Antagonists from a High-Throughput Screen.

Aaron M Bender, Michael S Valentine, Joshua A Bauer, Emily Days, Craig W Lindsley, W David Merryman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Assay and drug development technologies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Potent and Selective Human 5-HTJournal of medicinal chemistry · 2024
    Article
  2. Article
  3. DualACS medicinal chemistry letters · 2024
    Article
  4. Structure activity relationships of 5-HTEuropean journal of medicinal chemistry · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aaron M BenderWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Franklin, Tennessee, USA.ORCID 0000-0003-0432-1648
Michael S ValentineDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Joshua A BauerVanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA.
Emily DaysVanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA.
Craig W LindsleyWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Franklin, Tennessee, USA.
W David MerrymanDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Vanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
University of Iowa Clinical and Translational Science ProgramUL1TR000442 · NCATS · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2012 to 2013
$10.0M
Clinical and Translational Training Program in Pulmonary MedicineT32HL087738 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2007 to 2026
$7.0M
Cancer Pharmacologist and HTS ScientistR50CA211206 · NCI · VANDERBILT UNIVERSITY · PI Joshua A. Bauer · 2016 to 2026
$1.8M
Fluorescent and Luminescent Kinetic Imaging Plate ReaderS10OD021734 · OD · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG · 2016 to 2016
$671k
NCATS NIH HHS UL1 TR000442NCI NIH HHS P30 CA068485NCI NIH HHS R50 CA211206NHLBI NIH HHS T32 HL087738NIH HHS S10 OD021734
6 · The paper itself

Abstract

Antagonists of the serotonin receptor 2B (5-HT

Indexed as

Receptor, Serotonin, 5-HT2BSerotoninHumansReceptor, Serotonin, 5-HT2BSerotonin5-HT2B, pulmonary arterial hypertensionhigh-throughput screenserotonin

Identifiers

PMID36930852
PMCPMC10122230
OpenAlexW4327701545

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.