SynthesisBiological psychiatry2023
Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders.
Abstract readMeta-AnalysisReview
In one paragraph
Synthesis in Biological psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Genetic Architecture of the Human Corpus Callosum and its Subregions.Nature communications · 2025Pooled it
- A systematic review of air pollution exposure and brain structure and function during development.Environmental research · 2025Pooled it
- Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- The genetic architecture of cortical similarity networks.Nature communications · 2026Article
- Infant subcortical brain volumes associated with maternal obesity and diabetes: a large multicohort human study.BMC medicine · 2026Article
- Maternal depression with and without a history of childhood maltreatment and newborn white matter microstructure.Psychological medicine · 2026Article
- Klotho as a novel biomarker of attention-deficit hyperactivity disorder and related executive dysfunction.BJPsych open · 2026Article
- Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium.Molecular psychiatry · 2026Review
- Mapping brain growth and sex differences across prenatal to postnatal development.Scientific reports · 2026Article
- Fractal analysis of brain shape formation predicts age and genetic similarity in human newborns.Nature neuroscience · 2026Article
- Early-life neural correlates of behavioral inhibition and anxiety risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- [Research progress on the relationship between maternal depression and adolescent depressive symptoms and family-based interventions].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Review
- Sex differences in brain-behavior relationships in the first 2 years of life.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Emergence of a synergistic scaffold in the brains of human infants.Communications biology · 2025Article
- Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Association of anthropometric parameters with intelligence quotient in early school-aged children: a cross-sectional study in Iran.BMC pediatrics · 2024Article
- Brain age prediction and deviations from normative trajectories in the neonatal connectome.Nature communications · 2024Article
- A Systematic Review of Air Pollution Exposure and Brain Structure and Function during Development.medRxiv : the preprint server for health sciences · 2024Article
- Transcriptional patterns of amygdala functional connectivity in first-episode, drug-naïve major depressive disorder.Translational psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Ann M AlexInstitute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, Michigan.
Claudia BussCharité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Medical Psychology, Berlin, Germany; Department of Pediatrics, University of California Irvine, Irvine, California; Development, Health and Disease Research Program, University of California Irvine, Irvine, California.
Elysia Poggi DavisDepartment of Pediatrics, University of California Irvine, Irvine, California; Department of Psychology, University of Denver, Denver, Colorado.
Gustavo de Los CamposInstitute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, Michigan; Departments of Epidemiology & Biostatistics, Michigan State University, East Lansing, Michigan; Department of Statistics & Probability, Michigan State University, East Lansing, Michigan.
Kirsten A DonaldDivision of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Damien A FairMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, Minnesota; Institute of Child Development, College of Education and Human Development, University of Minnesota, Minneapolis, Minnesota; Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota.
Nadine GaabHarvard Graduate School of Education, Harvard University, Cambridge, Massachusetts.
Wei GaoCedars-Sinai Biomedical Imaging Research Institute, Los Angeles, California; Departments of Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, California.
John H GilmoreDepartment of Psychiatry, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina.
Jessica B GiraultDepartment of Psychiatry, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Carrboro, North Carolina.
Karen GrewenDepartment of Psychiatry, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina.
Nynke A GroenewoldNeuroscience Institute, University of Cape Town, Cape Town, South Africa; South African Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa; Department of Paediatrics and Child Health, University of Cape Town, Faculty of Health Sciences, Cape Town, South Africa.
Benjamin L HankinPsychology Department, University of Illinois Urbana,-Champaign, Illinois.
Jonathan IpserNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Shreya KapoorResearch Group Learning in Early Childhood, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Pilyoung KimDepartment of Psychology, University of Denver, Denver, Colorado.
Weili LinDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Shan LuoDepartment of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California; Department of Psychology, University of Southern California, Los Angeles, California; Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, California.
Elizabeth S NortonRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois; Department of Medical Social Sciences and Institute for Innovations in Developmental Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Thomas G O'ConnorDepartments of Psychiatry, Psychology, Neuroscience, Obstetrics and Gynecology, University of Rochester, Rochester, New York.
Joseph PivenDepartment of Psychiatry, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Carrboro, North Carolina.
Anqi QiuDepartment of Biomedical Engineering, National University of Singapore, Singapore; NUS (Suzhou) Research Institute, National University of Singapore, China; the Institute for Health, National University of Singapore, Singapore; School of Computer Engineering and Science, Shanghai University, Shanghai, China; Institute of Data Science, National University of Singapore, Singapore; Department of Biomedical Engineering, the Johns Hopkins University, Baltimore, Maryland.
Jerod M RasmussenDepartment of Pediatrics, University of California Irvine, Irvine, California; Development, Health and Disease Research Program, University of California Irvine, Irvine, California.
Michael A SkeideDepartment of Psychiatry, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina; Research Group Learning in Early Childhood, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Dan J SteinSouth African Medical Research Council Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, University of Cape Town, Cape Town, South Africa; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Martin A StynerDepartment of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Paul M ThompsonImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of the Sunshine Coast, Marina del Rey, California.
Laurie WakschlagDepartment of Medical Social Sciences and Institute for Innovations in Developmental Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Rebecca KnickmeyerInstitute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, Michigan; Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan. Electronic address: knickmey@msu.edu.
ENIGMA ORIGINs group
Funding
HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4MCellular and molecular mechanisms governing cortical surface area overgrowth in iPSC-derived neural cells from longitudinally characterized individuals with autismR01HD055741 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Piven · 2007 to 2026
$52.6MUNC MRDD Research CenterP30HD003110 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BURCHINAL, MARGARET · 1985 to 2012
$28.7MProspective study of the onset of schizophreniaP50MH064065 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2002 to 2011
$19.6MPre- and Postnatal Exposure Periods for Child Health: Common Risks and Shared MechanismsUH3OD023349 · OD · UNIVERSITY OF ROCHESTER · PI Emily S Barrett, Richard Kermit Miller · 2018 to 2026
$15.9MCross-Cultural Assessment of FASDU24AA014811 · NIAAA · SAN DIEGO STATE UNIVERSITY · PI EDWARD P RILEY · 2003 to 2026
$13.1MThe Developing Brain: Influences and OutcomesUG3OD023313 · OD · UNIVERSITY OF COLORADO DENVER · PI D'SA, VIREN ANDREW, KOINIS MITCHELL, DAPHNE · 2016 to 2024
$11.6MPRENATAL COCAINE AND NEUROBEHAVIORAL FACTORS UNDERLYING MOTHER-INFANT INTERACTIONP01DA022446 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOHNS, JOSEPHINE M. · 2008 to 2015
$10.2MPreclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7MPostdoctoral Research in Neurodevelopmental DisordersT32HD040127 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENJAMIN D PHILPOT, Mark D Shen · 2001 to 2026
$8.5MOptimizing prediction of preschool psychopathology from brain: behavior markers of emotion dysregulation from birth: A computational, developmental cognitive neuroscience approachR01MH121877 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUBY, JOAN L., ROGERS, CYNTHIA ELISE · 2020 to 2024
$8.2MPre- and Postnatal Exposure Periods for Child Health: Common Risks and Shared MechanismsUG3OD023349 · OD · UNIVERSITY OF ROCHESTER · PI BARRETT, EMILY S, MILLER, RICHARD KERMIT · 2016 to 2024
$7.0MNCRR NIH HHS UL1 RR025758NHLBI NIH HHS R01 HL155744NIAAA NIH HHS R01 AA026834NIAAA NIH HHS R21 AA023887NIAAA NIH HHS U24 AA014811NICHD NIH HHS P30 HD003110NICHD NIH HHS P50 HD103573NICHD NIH HHS R00 HD100593NICHD NIH HHS R01 HD053000NICHD NIH HHS R01 HD055741NICHD NIH HHS R01 HD060628NICHD NIH HHS R01 HD065762NICHD NIH HHS R01 HD090068NICHD NIH HHS T32 HD040127NIDA NIH HHS P01 DA022446NIH HHS UG3 OD023313NIH HHS UG3 OD023349NIH HHS UH3 OD023349NIMH NIH HHS K01 MH122779NIMH NIH HHS P50 MH064065NIMH NIH HHS R01 MH070890NIMH NIH HHS R01 MH092335NIMH NIH HHS R01 MH105538NIMH NIH HHS R01 MH107652NIMH NIH HHS R01 MH109662NIMH NIH HHS R01 MH121877NIMH NIH HHS R01 MH123716NIMH NIH HHS R21 MH104330NIMH NIH HHS R33 MH104330NIMH NIH HHS U01 MH070890NIMH NIH HHS U01 MH110274NINDS NIH HHS R01 NS055754Wellcome TrustWellcome Trust 203525/Z/16/Z
Abstract
Imaging genetics provides an opportunity to discern associations between genetic variants and brain imaging phenotypes. Historically, the field has focused on adults and adolescents; very few imaging genetics studies have focused on brain development in infancy and early childhood (from birth to age 6 years). This is an important knowledge gap because developmental changes in the brain during the prenatal and early postnatal period are regulated by dynamic gene expression patterns that likely play an important role in establishing an individual's risk for later psychiatric illness and neurodevelopmental disabilities. In this review, we summarize findings from imaging genetics studies spanning from early infancy to early childhood, with a focus on studies examining genetic risk for neuropsychiatric disorders. We also introduce the Organization for Imaging Genomics in Infancy (ORIGINs), a working group of the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium, which was established to facilitate large-scale imaging genetics studies in infancy and early childhood.
Indexed as
BrainMental DisordersChild, PreschoolFemaleHumansNeuroimagingPhenotypePregnancyChildhoodGeneticsImagingInfantMagnetic resonance imagingPediatric
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.