Evidence map›Paper›PMID 36932132›Full record

ArticleCommunications biology2023

Primary cilia control cellular patterning of Meibomian glands during morphogenesis but not lipid composition.

Céline Portal, Yvonne Lin, Varuni Rastogi, Cornelia Peterson, Samuel Chi-Hung Yiu, James W Foster, Amber Wilkerson, Igor A Butovich, Carlo Iomini

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Meibomian gland development: Where, when and how?Differentiation; research in biological diversity
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Céline PortalDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.ORCID 0000-0002-1862-0166
Yvonne Lin *Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Varuni Rastogi *Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Cornelia PetersonDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.ORCID 0000-0001-6550-1883
Samuel Chi-Hung YiuDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
James W FosterDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Amber WilkersonDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID 0000-0002-6204-3474
Igor A ButovichDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Carlo IominiDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA. ciomini1@jhmi.edu.ORCID 0000-0001-6483-9540
Johns Hopkins University · USThe University of Texas Southwestern Medical Center · USCentre National de la Recherche Scientifique · FR

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI JEFFREY MUMM · 1985 to 2026
$22.1M
Meibogenesis in Health, Disease, and Aging - Administrative SupplementR01EY027349 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI BUTOVICH, IGOR A · 2017 to 2025
$2.9M
Biosynthesis and physiological roles of extremely long chain lipids in the eyeR01EY024324 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI BUTOVICH, IGOR A · 2016 to 2019
$1.6M
Request for Zeiss LSM 510 MP Multiphoton Imaging SystemS10RR024550 · NCRR · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2008 to 2008
$500k
Role of Primary Cilia-mediated Signaling in Development and Regeneration of the Meibomian GlandsR21EY030661 · NEI · JOHNS HOPKINS UNIVERSITY · PI IOMINI, CARLO · 2020 to 2021
$444k
NCRR NIH HHS S10 RR024550NEI NIH HHS P30 EY001765NEI NIH HHS R01 EY024324NEI NIH HHS R01 EY027349NEI NIH HHS R21 EY030661
6 · The paper itself

Abstract

Meibomian glands (MGs) are modified sebaceous glands producing the tear film's lipids. Despite their critical role in maintaining clear vision, the mechanisms underlying MG morphogenesis in development and disease remain obscure. Cilia-mediate signals are critical for the development of skin adnexa, including sebaceous glands. Thus, we investigated the role of cilia in MG morphogenesis during development. Most cells were ciliated during early MG development, followed by cilia disassembly during differentiation. In mature glands, ciliated cells were primarily restricted to the basal layer of the proximal gland central duct. Cilia ablation in keratine14-expressing tissue disrupted the accumulation of proliferative cells at the distal tip but did not affect the overall rate of proliferation or apoptosis. Moreover, impaired cellular patterning during elongation resulted in hypertrophy of mature MGs with increased meibum volume without altering its lipid composition. Thus, cilia signaling networks provide a new platform to design therapeutic treatments for MG dysfunction.

Indexed as

CiliaMeibomian GlandsApoptosisMorphogenesisTears

Identifiers

PMID36932132
PMCPMC10023665
OpenAlexW4327728477

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read66
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.