Evidence map›Paper›PMID 36933145›Full record

ArticleMolecular neurobiology2023

Delivery of miR-130a-3p Through Adipose-Derived Stem Cell-Secreted EVs Protects Against Diabetic Peripheral Neuropathy via DNMT1/NRF2/HIF1α/ACTA1 Axis.

Ji Chen, Gengzhang Li, Xinxin Liu, Kemin Chen, Yuxia Wang, Jie Qin, Fengrui Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

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  8. Veterinary world · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ji Chen *Department of Endocrinology, The First People's Hospital of Huaihua, Huaihua, 418000, People's Republic of China.
Gengzhang Li *Department of Anesthesiology, The First Affiliated Hospital, Shaoyang College, Shaoyang, 422001, People's Republic of China.
Xinxin Liu *Department of Anesthesiology, The First People's Hospital of Huaihua, No. 144, Jinxi South Road, Huaihua, 418000, Hunan Province, People's Republic of China.
Kemin ChenDepartment of Anesthesiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, People's Republic of China.
Yuxia WangDepartment of Anesthesiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, People's Republic of China.
Jie QinDepartment of Anesthesiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, People's Republic of China.
Fengrui YangDepartment of Anesthesiology, The First People's Hospital of Huaihua, No. 144, Jinxi South Road, Huaihua, 418000, Hunan Province, People's Republic of China. 332530935@qq.com.ORCID http://orcid.org/0000-0002-8558-1419
Huaian First People’s Hospital · CNUniversity of South China · CN

Funding

Natural Science Foundation of Hunan Province 2021JJ70043Project of Hunan Provincial Department of Education 19B477Project of Hunan Provincial Health Commission 20200018Project of Hunan Provincial Health Commission 20200037
6 · The paper itself

Abstract

Peripheral neuropathy is common in diabetic patients and can lead to amputations or foot ulcers. microRNAs (miRNAs) possess crucial roles in diabetic peripheral neuropathy (DPN). This study aims to investigate the role miR-130a-3p played in DPN and its underlying molecular mechanisms. miR-130a-3p expression in clinical tissue samples, established DPN rat models, and extracellular vesicles (EVs) derived from adipose-derived stem cells (ADSCs) were determined. Schwann cells (SCs) were co-cultured with ADSC-derived EVs and treated with high glucose. The direct relationship and functional significance of miR-130a-3p, DNMT1, nuclear factor E2-related factor 2 (NRF2), hypoxia-inducible factor-1α (HIF1α), and skeletal muscle actin alpha 1 (ACTA1) was identified. The in vitro and in vivo implication of ADSC-derived EVs carrying miR-130a-3p was assessed. miR-130a-3p was poorly expressed in DPN patients and rats but highly expressed in ADSC-derived EVs. miR-130a-3p could be delivered to SCs through ADSC-derived EVs to inhibit SC apoptosis and promote proliferation under a high-glucose environment. miR-130a-3p activated NRF2/HIF1α/ACTA1 axis through down-regulating DNMT1. In vivo injection of ADSC-derived EVs activated NRF2/HIF1α/ACTA11 axis to promote angiogenesis in DPN rat model. These data together supported that ADSC-derived EVs carrying miR-130a-3p could alleviate DPN by accelerating SC proliferation and inhibiting apoptosis, providing a potential treatment against DPN.

Indexed as

Diabetes MellitusDiabetic NeuropathiesExtracellular VesiclesMicroRNAsActinsAnimalsGlucoseHypoxia-Inducible Factor 1, alpha SubunitNF-E2-Related Factor 2RatsStem CellsActinsGlucoseHypoxia-Inducible Factor 1, alpha SubunitMicroRNAsNF-E2-Related Factor 2Adipose-derived stem cellDiabetic peripheral neuropathyDNMT1Extracellular vesiclesHypoxia-inducible factor-1αmicroRNA-130a-3pNuclear factor E2-related factor 2Schwann cellSkeletal muscle actin alpha 1

Identifiers

PMID36933145
OpenAlexW4327723634

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.