Evidence map›Paper›PMID 36935324›Full record

ReviewThe Journal of hand surgery2023

Pharmacotherapies in Dupuytren Disease: Current and Novel Strategies.

Alex G Lambi, Steven N Popoff, Prosper Benhaim, Mary F Barbe

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of hand surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Alex G LambiDepartment of Orthopedics and Rehabilitation, University of New Mexico School of Medicine, Albuquerque, NM. Electronic address: alambi@salud.unm.edu.
Steven N PopoffDepartment of Orthopaedic Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA; Department of Biomedical Education and Data Science, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Prosper BenhaimDepartment of Orthopaedic Surgery, University of California Los Angeles, Los Angeles, CA.
Mary F BarbeDepartment of Biomedical Education and Data Science, Lewis Katz School of Medicine at Temple University, Philadelphia, PA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Temple University · USUniversity of California, Los Angeles · USUniversity of New Mexico · US

Funding

Biomarkers of Tissue Tolerance and Behavior in a Rat ModelR01AR056019 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI BARBE, MARY F · 2009 to 2025
$7.3M
NIAMS NIH HHS R01 AR056019
6 · The paper itself

Abstract

Dupuytren disease is a benign, progressive fibroproliferative disorder of the hands. To date, only one pharmacotherapy (clostridial collagenase) has been approved for use in Dupuytren disease. There is a great need for additional nonsurgical methods that can be used to either avoid the risks of invasive treatments or help minimize recurrence rates following treatment. A number of nonsurgical modalities have been discussed in the past and continue to appear in discussions among hand surgeons, despite highly variable and often poor or no long-term clinical data. This article reviews many of the pharmacotherapies discussed in the treatment of Dupuytren disease and novel therapies used in inflammation and fibrosis that offer potential treatment options.

Indexed as

Dupuytren ContractureHathewaya histolyticaHumansInjections, IntralesionalMicrobial CollagenaseTreatment OutcomeMicrobial CollagenaseCollagenaseDupuytrenfibrosismyofibroblastTGF-beta

Identifiers

PMID36935324
PMCPMC10440226
OpenAlexW4327705408

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.