Evidence map›Paper›PMID 36936979›Full record

ArticleFrontiers in immunology2023

COVID-19 spike polypeptide vaccine reduces the pathogenesis and viral infection in a mouse model of SARS-CoV-2.

Yasmin Hisham, Sun-Min Seo, Sinae Kim, Saerok Shim, Jihyeong Hwang, Eun-Seon Yoo, Na-Won Kim, Chang-Seon Song, Hyunjhung Jhun, Ho-Young Park and 6 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Yasmin HishamLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea.
Sun-Min SeoDepartment of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Sinae KimLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea.
Saerok ShimLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea.
Jihyeong HwangLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea.
Eun-Seon YooDepartment of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Na-Won KimDepartment of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Chang-Seon SongCollege of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Hyunjhung JhunFood Industry Infrastructure Team, Korea Food Research Institute, Wanju, Republic of Korea.
Ho-Young ParkResearch Group of Functional Food Materials, Korea Food Research Institute, Wanju, Republic of Korea.
Youngmin LeeDepartment of Medicine, Pusan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Kyeong-Cheol ShinCenter for Respiratory Disease, College of Medicine, Yeungnam University, Daegu, Republic of Korea.
Sun-Young HanCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongsangnam, Republic of Korea.
Je Kyung SeongLaboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Science Research, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Yang-Kyu ChoiDepartment of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Soohyun KimLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea.
Konkuk University · KRInje University Busan Paik Hospital · KRSeoul National University · KRGyeongsang National University · KRKorea Food Research Institute · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 coronavirus, which causes a respiratory disease called COVID-19, has been declared a pandemic by the World Health Organization (WHO) and is still ongoing. Vaccination is the most important strategy to end the pandemic. Several vaccines have been approved, as evidenced by the ongoing global pandemic, but the pandemic is far from over and no fully effective vaccine is yet available. One of the most critical steps in vaccine development is the selection of appropriate antigens and their proper introduction into the immune system. Therefore, in this study, we developed and evaluated two proposed vaccines composed of single and multiple SARS-CoV-2 polypeptides derived from the spike protein, namely, vaccine A and vaccine B, respectively. The polypeptides were validated by the sera of COVID-19-vaccinated individuals and/or naturally infected COVID-19 patients to shortlist the starting pool of antigens followed by

Indexed as

COVID-19Virus DiseasesAnimalsCOVID-19 VaccinesDisease Models, AnimalMiceMice, TransgenicPeptidesSARS-CoV-2COVID-19 VaccinesPeptidesCOVID-19 vaccinein vivo mouse modelpathogenesisSARS-CoV-2spike polypeptide

Identifiers

PMID36936979
PMCPMC10020603
OpenAlexW4323314322

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read19
identifiers read4
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.