ArticleGeneral psychiatry2023
Shared genetics and bidirectional causal relationships between type 2 diabetes and attention-deficit/hyperactivity disorder.
Article in General psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Mapping genetic convergence across brain structure, mental health, and cardiometabolic disease.Communications medicine · 2026Article
- Multi-Level Latent Variable Models for Coheritability Analysis in Electronic Health Records.Statistics in medicine · 2026Article
- Update on ADHD genetics: A practitioner's perspective: Mise à jour sur la génétique du TDAH : le point de vue d'un praticien.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2026Review
- Shared genetic variants across substance use disorders implicate common neurobiological pathways, a genome-wide mixed methods study.General psychiatry · 2026Article
- Exploring Causal Associations Between Plasma Metabolites and Autism Spectrum Disorder.Alpha psychiatry · 2025Article
- Fat-brain axis indicated by mutual impacts between body fat and brain phenotypes.Journal of translational medicine · 2025Article
- Causal Influences of Micronutrients on Anxiety: Insights From an Observational and Mendelian Randomization Analysis.Food science & nutrition · 2025Article
- The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities.Nature communications · 2025Article
- Familial co-aggregation and shared heritability between clinically diagnosed neurodevelopmental problems and cardiometabolic conditions: a nationwide register study across three generations.Research square · 2025Article
- Opposite causal effects of type 2 diabetes and metformin on Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2025Article
- The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities.medRxiv : the preprint server for health sciences · 2025Article
- Gut microbiome links obesity to type 2 diabetes: insights from Mendelian randomization.BMC microbiology · 2025Article
- Causal Relationships Between Retinal Diseases and Psychiatric Disorders Have Implications for Precision Psychiatry.Molecular neurobiology · 2025Article
- Causal associations between posttraumatic stress disorder and type 2 diabetes.Diabetology & metabolic syndrome · 2025Article
- Investigating bidirectional causal relationships between gut microbiota and insomnia.General psychiatry · 2025Article
- Mediating pathways between attention deficit hyperactivity disorder and type 2 diabetes mellitus: evidence from a two-step and multivariable Mendelian randomization study.Epidemiology and psychiatric sciences · 2024Article
- Gut microbiome and schizophrenia: insights from two-sample Mendelian randomization.Schizophrenia (Heidelberg, Germany) · 2024Article
- Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians.Nature communications · 2024Article
- Bidirectional associations between mental disorders, antidepressants and cardiovascular disease.BMJ mental health · 2024Article
- Quantifying the Relative Importance of Genetics and Environment on the Comorbidity between Mental- and Cardiometabolic Disorders: A Comprehensive Analysis of National Register Data from 17 million Scandinavians.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Type 2 diabetes (T2D) is a chronic metabolic disorder with high comorbidity with mental disorders. The genetic links between attention-deficit/hyperactivity disorder (ADHD) and T2D have yet to be elucidated. Aims: We aim to assess shared genetics and potential associations between ADHD and T2D. Methods: We performed genetic correlation, two-sample Mendelian randomisation and polygenic overlap analyses between ADHD and T2D. The genome-wide association study (GWAS) summary results of T2D (80 154 cases and 853 816 controls), ADHD2019 (20 183 cases and 35 191 controls from the 2019 GWAS ADHD dataset) and ADHD2022 (38 691 cases and 275 986 controls from the 2022 GWAS ADHD dataset) were used for the analyses. The T2D dataset was obtained from the DIAGRAM Consortium. The ADHD datasets were obtained from the Psychiatric Genomics Consortium. We compared genome-wide association signals to reveal shared genetic variation between T2D and ADHD using the larger ADHD2022 dataset. Moreover, molecular pathways were constructed based on large-scale literature data to understand the connection between ADHD and T2D. Results: T2D has positive genetic correlations with ADHD2019 (r Conclusions: Our study demonstrates substantial shared genetics and bidirectional causal associations between ADHD and T2D.
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