Evidence map›Paper›PMID 36939086›Full record

ArticleSchizophrenia bulletin2023

Self-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis.

Erica L Karp, Trevor F Williams, Lauren M Ellman, Gregory P Strauss, Elaine F Walker, Philip R Corlett, Scott W Woods, Albert R Powers, James M Gold, Jason E Schiffman and 3 more

Open access · greenAbstract read
In one paragraph

Article in Schizophrenia bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Erica L KarpDepartment of Psychology, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-6585-0132
Trevor F WilliamsDepartment of Psychology, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-2202-7020
Lauren M EllmanDepartment of Psychology, Temple University, Philadelphia, PA 19122, USA.
Gregory P StraussDepartments of Psychology and Neuroscience, University of Georgia, Athens, GA 30602, USA.
Elaine F WalkerDepartment of Psychology and Program in Neuroscience, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-9798-8101
Philip R CorlettDepartment of Psychiatry, Yale University, New Haven, CT 06519, USA.ORCID 0000-0002-5368-1992
Scott W WoodsDepartment of Psychiatry, Yale University, New Haven, CT 06519, USA.
Albert R PowersDepartment of Psychiatry, Yale University, New Haven, CT 06519, USA.ORCID 0000-0003-3057-5043
James M GoldMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA.
Jason E SchiffmanDepartment of Psychological Science, University of California, 4201 Social and Behavioral Sciences Gateway, Irvine, CA 92697, USA.
James A WaltzMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA.ORCID 0000-0002-9236-3719
Steven M SilversteinDepartments of Psychiatry, Neuroscience and Ophthalmology, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0002-0699-0960
Vijay A MittalInstitutes for Policy Research (IPR) and Innovations in Developmental Sciences (DevSci), Departments of Psychology, Psychiatry, Medical Social Sciences, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-9017-5119
Northwestern University · USYale University · USUniversity of Maryland, Baltimore · USEmory University · USTemple University · USUniversity of California, Irvine · USUniversity of Georgia · USUniversity of Rochester Medical Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
1/5 CAPER: Computerized Assessment of ProdromE RiskR01MH120090 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI GOLD, JAMES M. · 2020 to 2024
$2.9M
2/5 CAPER Computerized assessment of psychosis riskR01MH120088 · NIMH · NORTHWESTERN UNIVERSITY · PI MITTAL, VIJAY A · 2020 to 2024
$2.0M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH120088NIMH NIH HHS R01 MH120090
6 · The paper itself

Abstract

background and hypothesisDeficits in performing and interpreting communicative nonverbal behaviors, such as gesture, have been linked to varied psychopathology and dysfunction. Some evidence suggests that individuals at risk for psychosis have deficits in gesture interpretation and performance; however, individuals with internalizing disorders (eg, depression) may have similar deficits. No previous studies have examined whether gesture deficits in performance and interpretation are specific to those at risk for psychosis. Additionally, the underlying mechanisms (eg, cognition) and consequences (eg, functioning) of these deficits are poorly understood. STUDY

designThis study examined self-reported gesture interpretation (SRGI) and performance (SRGP) in those at clinical high risk for psychosis (CHR; N = 88), those with internalizing disorders (INT; N = 51), and healthy controls (HC; N = 53). Participants completed questionnaires, clinical interviews, and neurocognitive tasks. STUDY

resultsResults indicated that the CHR group was characterized by significantly lower SRGI scores than the HC or INT groups (d = 0.41); there were no differences among groups in SRGP. Within CHR participants, greater deficits in SRGP were associated with lower verbal learning and memory (r = -.33), but not general intelligence or processing speed. Furthermore, gesture deficits were associated with higher cross-sectional risk for conversion to a full psychotic disorder in the CHR group.

conclusionsOverall, these findings suggest that specific subdomains of gesture may reflect unique vulnerability for psychosis, self-report may be a viable assessment tool in understanding these phenomena, and gesture dysfunction may signal risk for transition to psychosis.

Indexed as

GesturesPsychotic DisordersCross-Sectional StudiesHumansNeuropsychological TestsProdromal SymptomsSelf ReportCHRcognitiongestureprodromeworking memory

Identifiers

PMID36939086
PMCPMC10154698
OpenAlexW4327896579

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.