Evidence map›Paper›PMID 36939201›Full record

ArticleAmerican journal of physiology. Cell physiology2023

Mfge8 is expressed by pericytes in gastric antrum submucosa from patients with obesity.

Brian A Perrino, Justin Malogan, Caroline A Cobine, Kent C Sasse

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Brian A PerrinoDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, Nevada, United States.ORCID 0000-0001-7429-9971
Justin MaloganDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, Nevada, United States.
Caroline A CobineDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, Nevada, United States.
Kent C SasseNevada Surgical Associates, Reno, Nevada, United States.
University of Nevada, Reno · US

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
Control of motility in the lower esophageal sphincterR01DK129528 · NIDDK · UNIVERSITY OF NEVADA RENO · PI COBINE, CAROLINE ANN · 2021 to 2025
$2.1M
NIDDK NIH HHS R01 DK129528NIDDK NIH HHS U24 DK076169
6 · The paper itself

Abstract

The main function of the stomach is to digest ingested food. Gastric antrum muscular contractions mix ingested food with digestive enzymes and stomach acid and propel the chyme through the pyloric sphincter at a rate in which the small intestine can process the chyme for optimal nutrient absorption. Mfge8 binding to α8β1 integrins helps regulate gastric emptying by reducing the force of antral smooth muscle contractions. The source of Mfge8 within gastric muscles is unclear. Since Mfge8 is a secreted protein, Mfge8 could be delivered via the circulation, or be locally secreted by cells within the muscle layers. In this study, we identify a source of Mfge8 within human gastric antrum muscles using spatial transcriptomic analysis. We show that Mfge8 is expressed in subpopulations of Mef2c

Indexed as

PericytesPyloric AntrumAntigens, SurfaceEndothelial CellsGastric EmptyingHumansIntegrinsMilk ProteinsObesityPylorusReceptor, Platelet-Derived Growth Factor betaAntigens, SurfaceIntegrinsMFGE8 protein, humanMilk ProteinsReceptor, Platelet-Derived Growth Factor betagastric emptyinggastric submucosaMfge8microcirculationpericytes

Identifiers

PMID36939201
PMCPMC10110711
OpenAlexW4327896583

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.