Evidence map›Paper›PMID 36940740›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2023

Fructose: A New Variable to Consider in SIADH and the Hyponatremia Associated With Long-Distance Running?

Richard J Johnson, S M Kurt Lee, Laura G Sánchez-Lozada, Mehmet Kanbay, Anip Bansal, Dean R Tolan, Petter Bjornstad, Miguel A Lanaspa, John Maesaka

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Richard J JohnsonDivision of Renal Diseases and Hypertension, Anschutz Medical Campus, University of Colorado, Aurora, Colorado. Electronic address: richard.johnson@cuanschutz.edu.
S M Kurt LeeNeches Clinic, Beaumont, Texas.
Laura G Sánchez-LozadaDepartment of Cardio-Renal Physiopathology, INC Ignacio Chávez, Mexico City, Mexico.
Mehmet KanbayDivision of Nephrology, Department of Medicine, School of Medicine, Koc University, Istanbul, Turkey.
Anip BansalDivision of Renal Diseases and Hypertension, Anschutz Medical Campus, University of Colorado, Aurora, Colorado.
Dean R TolanBiology Department, Boston University, Boston Massachusetts.
Petter BjornstadDivision of Renal Diseases and Hypertension, Anschutz Medical Campus, University of Colorado, Aurora, Colorado; Section of Endocrinology, Department of Pediatrics, Anschutz Medical Campus, University of Colorado, Aurora, Colorado.
Miguel A LanaspaDivision of Renal Diseases and Hypertension, Anschutz Medical Campus, University of Colorado, Aurora, Colorado.
John MaesakaDepartment of Medicine and Division of Nephrology and Hypertension, NYU Langone Hospitals, Mineola, New York.
University of Colorado Anschutz Medical Campus · USBoston University · USInstituto Nacional de Cardiología · MXKoç University · TR

Funding

NIDDK NIH HHS R01 DK121496
6 · The paper itself

Abstract

Fructose has recently been proposed to stimulate vasopressin secretion in humans. Fructose-induced vasopressin secretion is not only postulated to result from ingestion of fructose-containing drinks but may also occur from endogenous fructose production via activation of the polyol pathway. This raises the question of whether fructose might be involved in some cases of vasopressin-induced hyponatremia, especially in situations where the cause is not fully known such as in the syndrome of inappropriate secretion of diuretic hormone (SIADH) and exercise-associated hyponatremia, which has been observed in marathon runners. Here we discuss the new science of fructose and vasopressin, and how it may play a role in some of these conditions, as well as in the complications associated with rapid treatment (such as the osmotic demyelination syndrome). Studies to test the role of fructose could provide new pathophysiologic insights as well as novel potential treatment strategies for these common conditions.

Indexed as

HyponatremiaInappropriate ADH SyndromeRunningDiureticsHumansVasopressinsDiureticsVasopressinsFructosehyponatremiaosmotic demyelination syndromepolyol pathwaySIADH

Identifiers

PMID36940740
PMCPMC10330032
OpenAlexW4327921905

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.