SynthesisNature genetics2023
Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
36.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects.Nature genetics · 2025Pooled it
- SPLENDID incorporates continuous genetic ancestry in biobank-scale data to improve polygenic risk prediction across diverse populations.Nature methods · 2026Article
- All of Us diversity and scale yield context-dependent improvements in polygenic prediction.Nature genetics · 2026Article
- Decoding Primary Open-Angle Glaucoma: A Multi-Omics Approach to Identify Druggable Effector Genes.Investigative ophthalmology & visual science · 2026Article
- Partitioned blood pressure polygenic risk reveals differential genetic effects of tissue-specific enhancers and their interactions on cardiovascular disease.Research square · 2026Article
- Protocol for leveraging local ancestry and cross-ancestry genetic architecture to improve polygenic prediction in admixed populations.STAR protocols · 2026Article
- Large-scale admixture mapping in the All of Us Research Program improves the characterization of cross-population phenotypic differences.Nature communications · 2026Article
- Extending genome-wide association studies to admixed cohorts with high degrees of relatedness.Nature genetics · 2026Article
- An efficient LASSO framework for admixture-aware polygenic scores.HGG advances · 2026Article
- Article
- Multiple instance fine-mapping: Predicting causal regulatory variants with a deep sequence model.PLoS genetics · 2026Article
- Systematic common and rare variant association testing in 392,030 whole genomes inmedRxiv : the preprint server for health sciences · 2026Article
- Genomic Insights Into Inflammatory Bowel Disease in United States Hispanic Participants: An Ancestry-Focused Study.Gastroenterology · 2026Article
- Insights into the Cross-Population Transferability of Polygenic Scores for Substance Use.Behavior genetics · 2026Article
- Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in research.American journal of human genetics · 2026Review
- Genes that increase the risk of autism are shared across ancestries.Nature medicine · 2026Article
- Deleterious coding variation associated with autism is shared across ancestries.Nature medicine · 2026Article
- Genome-wide fine-mapping improves identification of causal variants.Nature genetics · 2026Article
- Representation in genetic studies affects inference about genetic architecture.bioRxiv : the preprint server for biology · 2026Article
- Proceedings of the second Artificial Intelligence in Primary Immunodeficiency (AIPI) meeting.The Journal of allergy and clinical immunology · 2026Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
29 authors at 13 institutions in 1 country.
Kangcheng HouBioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA. houkc@ucla.edu.ORCID http://orcid.org/0000-0001-7110-5596
Yi DingBioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA.
Ziqi XuDepartment of Computer Science, UCLA, Los Angeles, CA, USA.
Yue WuDepartment of Computer Science, UCLA, Los Angeles, CA, USA.
Arjun BhattacharyaDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1196-4385
Rachel MesterGraduate Program in Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6498-7727
Gillian M Belbin *Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Steve Buyske *Department of Statistics, Rutgers University, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0001-8539-5416
David V Conti *Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Burcu F Darst *Division of Public Health Science, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Myriam Fornage *Brown Foundation Institute for Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Chris Gignoux *Division of Biomedical Informatics and Personalized Medicine, University of Colorado, Denver, CO, USA.
Xiuqing Guo *Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0002-5264-5068
Christopher Haiman *Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Eimear E Kenny *Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michelle Kim *Division of Public Health Science, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Charles Kooperberg *Division of Public Health Science, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7986-8560
Leslie Lange *Department of Medicine, University of Colorado, Aurora, CO, USA.
Ani Manichaikul *Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Kari E North *Department of Statistics, Rutgers University, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0002-8903-0366
Ulrike Peters *Division of Public Health Science, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5666-9318
Laura J Rasmussen-Torvik *Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Stephen S Rich *Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-3872-7793
Jerome I Rotter *Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Heather E Wheeler *Department of Biology, Loyola University Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-1365-9667
Genevieve L Wojcik *Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7206-8088
Ying Zhou *Division of Public Health Science, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Sriram SankararamanBioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA.
Bogdan PasaniucBioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA. pasaniuc@ucla.edu.ORCID http://orcid.org/0000-0002-0227-2056
University of California, Los Angeles · USFred Hutch Cancer Center · USGenomic Health (United States) · USRutgers, The State University of New Jersey · USUCLA Medical Center · USUniversity of Southern California · USUniversity of Virginia · USBrown Foundation · USJohns Hopkins University · USLoyola University Chicago · USNorthwestern University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · US
Funding
Technology to Empower Changes in Health (TECH) Network Participant Technologies CenterU24OD023176 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2016 to 2022
$204.7MPrecision Medicine Initiative Cohort Program BiobankU24OD023121 · OD · MAYO CLINIC ROCHESTER · PI CEKANOVA, MARIA, CICEK, MINE · 2016 to 2024
$185.5MEnhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research CenterU2COD023196 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, DAVID, HARRIS, PAUL A. · 2016 to 2022
$143.7MAdaptive Platform for Personalized EngagementU24OD023163 · OD · VIGNET, INC. · PI JAIN, PRADUMAN · 2017 to 2020
$102.6MUniversity of Arizona-Banner Health All of Us Research Program OT2OD026549 · OD · UNIVERSITY OF ARIZONA · PI MORENO, FRANCISCO A, REIMAN, ERIC MICHAEL · 2018 to 2023
$78.9MCalifornia Precision Medicine Research Program ConsortiumOT2OD026552 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANTON-CULVER, HODA A, OHNO-MACHADO, LUCILA · 2018 to 2023
$73.4MAll of Us PennsylvaniaOT2OD026554 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E, VISWESWARAN, SHYAM · 2018 to 2023
$72.1MNew York City Consortium for Precision MedicineOT2OD026556 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BIER, LOUISE E, GHARAVI, ALI G · 2018 to 2023
$67.3MSouthEast Enrollment Center (SEEC) OT2OD026551 · OD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, COLON, VIVIAN · 2018 to 2023
$62.8MSouthern All of Us NetworkOT2OD026548 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N., KORF, BRUCE R · 2018 to 2023
$60.5MIllinois Precision Medicine Consortium OT2OD026557 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AHSAN, HABIBUL, ARGOS, MARIA · 2018 to 2023
$60.5MThe New England Precision Medicine Consortium of the All of Us Research ProgramOT2OD026553 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CLARK, CHERYL RENEE, KARLSON, ELIZABETH W · 2018 to 2023
$58.8MNCI NIH HHS P01 CA196569NCI NIH HHS U01 CA261339NHGRI NIH HHS R01 HG006399NHGRI NIH HHS R01 HG009120NHGRI NIH HHS R01 HG010297NHGRI NIH HHS R15 HG009569NHGRI NIH HHS U01 HG011715NHLBI NIH HHS R01 HL151152NIGMS NIH HHS R35 GM125055NIH HHS OT2 OD023205NIH HHS OT2 OD023206NIH HHS OT2 OD025276NIH HHS OT2 OD025277NIH HHS OT2 OD025315NIH HHS OT2 OD025337NIH HHS OT2 OD026548NIH HHS OT2 OD026549NIH HHS OT2 OD026550NIH HHS OT2 OD026551NIH HHS OT2 OD026552NIH HHS OT2 OD026553NIH HHS OT2 OD026554NIH HHS OT2 OD026555NIH HHS OT2 OD026556NIH HHS OT2 OD026557NIH HHS U24 OD023121NIH HHS U24 OD023163NIH HHS U24 OD023176NIH HHS U2C OD023196NIMH NIH HHS R01 MH115676
Abstract
Individuals of admixed ancestries (for example, African Americans) inherit a mosaic of ancestry segments (local ancestry) originating from multiple continental ancestral populations. This offers the unique opportunity of investigating the similarity of genetic effects on traits across ancestries within the same population. Here we introduce an approach to estimate correlation of causal genetic effects (r
Indexed as
Genetics, PopulationMultifactorial InheritanceBlack or African AmericanGenome-Wide Association StudyHumansPolymorphism, Single NucleotideRacial Groups
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What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.