Evidence map›Paper›PMID 36942145›Full record

ArticleThe Pan African medical journal2022

BRCA1 gene polymorphism and finger dermatoglyphic patterns in Ghanaian breast cancer patients: a quantitative cross-sectional approach.

Emmanuel Osei Nkansah, John Ahenkorah, Kevin Adutwum-Ofosu, Raymond Lovelace Adjei, Nii Armah Adu-Aryee, Emmanuel Ayitey Tagoe, Nii Koney-Kwaku Koney, Nii Ayite Aryee, Bismark Afedo Hottor, Richard Michael Blay and 2 more

Full text read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Pan African medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emmanuel Osei NkansahDepartment of Anatomy, University of Ghana Medical School, University of Ghana, Accra, Ghana.
John AhenkorahDepartment of Anatomy, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Kevin Adutwum-OfosuDepartment of Anatomy, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Raymond Lovelace AdjeiWest African Center for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Accra, Ghana.
Nii Armah Adu-AryeeDepartment of Surgery, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Emmanuel Ayitey TagoeDepartment of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.
Nii Koney-Kwaku KoneyDepartment of Anatomy, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Nii Ayite AryeeDepartment of Medical Biochemistry, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Bismark Afedo HottorDepartment of Anatomy, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Richard Michael BlayDepartment of Anatomy, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Joe-Nat Clegg-LampteyDepartment of Surgery, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Benjamin Arko-BohamDepartment of Anatomy, University of Ghana Medical School, University of Ghana, Accra, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: breast cancer development is linked to mutant single nucleotide polymorphism of breast cancer type 1 (BRCA1) gene usually harboured within exon 11. It has also been linked to finger dermatoglyphics where certain patterns have been associated with breast cancer. This study suggests a possible relationship between finger dermatoglyphic patterns and single nucleotide polymorphism of BRCA1 gene. Methods: in a quantitative cross-sectional approach, finger dermatoglyphic patterns were obtained using the ink method from 70 female breast cancer patients and 70 age-matched apparently healthy females. Approximately 5 ml of venous blood was obtained from each participant from which DNA was extracted from the white blood cells collected after centrifugation. DNA was amplified and sequenced and the data aligned with the wildtype template of BRCA1 gene. Fingerprint patterns were analyzed with Chi-square. Mean frequency of fingerprint patterns was analyzed with independent student's t-test. Differences in data set with p<0.05 were statistically significant. Results: luminal B was the predominant breast cancer molecular subtype among the patients. The predominant fingerprint pattern among breast cancer participants was the loop. Six or more loops had higher frequency among breast cancer females. The predominant BRCA1 gene variant locations were c.34311, c.34320, and c.34321 with c.34311A>C being the predominant variant. Higher percentage frequency of six or more loops in relation to c.34311A>C was observed in apparently healthy females compared to breast cancer females. Conclusion: the study reports for the very first time in Ghana, BRCA1 gene variants and finger dermatoglyphics among breast cancer patients. Although the results are preliminary and inconclusive it creates an avenue for extended studies.

Indexed as

Breast NeoplasmsGenes, BRCA1BRCA1 ProteinDermatoglyphicsFemaleGhanaHumansPolymorphism, Single NucleotideBRCA1 ProteinBRCA1 protein, humanBRCA1 geneBreast cancerfinger dermatoglyphicssingle nucleotide polymorphisms

Identifiers

PMID36942145
PMCPMC10024563

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read80
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.