Evidence map›Paper›PMID 36944419›Full record

ArticleLife science alliance2023

Cell death and barrier disruption by clinically used iodine concentrations.

Anne Steins, Christina Carroll, Fui Jiun Choong, Amee J George, Jin-Shu He, Kate M Parsons, Shouya Feng, Si Ming Man, Cathelijne Kam, Lex M van Loon and 7 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Efficacy of Mouthwashes Delivered via Dental Unit Waterlines in Reducing Aerosolized Surrogate SARS-CoV-2.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Frontiers in veterinary science · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 2 countries.

Anne SteinsDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, Australian National University, Acton, Australia.ORCID https://orcid.org/0000-0003-1493-4325
Christina CarrollCollege of Health and Medicine, Australian National University, Acton, Australia.ORCID https://orcid.org/0000-0001-7249-7149
Fui Jiun ChoongDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, Australian National University, Acton, Australia.
Amee J GeorgeDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, Australian National University, Acton, Australia.ORCID https://orcid.org/0000-0002-0265-4476
Jin-Shu HeDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, Australian National University, Acton, Australia.
Kate M ParsonsDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, Australian National University, Acton, Australia.
Shouya FengDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, Australian National University, Acton, Australia.
Si Ming ManDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, Australian National University, Acton, Australia.
Cathelijne KamDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, Australian National University, Acton, Australia.ORCID https://orcid.org/0009-0001-8894-7797
Lex M van LoonDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, Australian National University, Acton, Australia.
Perlita PohDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, Australian National University, Acton, Australia.ORCID https://orcid.org/0000-0001-9328-7685
Rita FerreiraDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, Australian National University, Acton, Australia.
Graham J MannDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, Australian National University, Acton, Australia.ORCID https://orcid.org/0000-0003-1301-405X
Russell L GruenCollege of Health and Medicine, Australian National University, Acton, Australia.
Katherine M HannanDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, Australian National University, Acton, Australia.
Ross D HannanDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, Australian National University, Acton, Australia.
Klaus-Martin SchulteDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, Australian National University, Acton, Australia km.schulte@anu.edu.au.ORCID https://orcid.org/0000-0002-9091-0512
Australian National University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Povidone-iodine (PVP-I) inactivates a broad range of pathogens. Despite its widespread use over decades, the safety of PVP-I remains controversial. Its extended use in the current SARS-CoV-2 virus pandemic urges the need to clarify safety features of PVP-I on a cellular level. Our investigation in epithelial, mesothelial, endothelial, and innate immune cells revealed that the toxicity of PVP-I is caused by diatomic iodine (I

Indexed as

Anti-Infective Agents, LocalCOVID-19IodineCell DeathHumansPovidone-IodineSARS-CoV-2Anti-Infective Agents, LocalIodinePovidone-Iodine

Identifiers

PMID36944419
PMCPMC10031031
OpenAlexW4328089017

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read90
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.