Evidence map›Paper›PMID 36944420›Full record

ArticleLife science alliance2023

Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes.

Flora Crozet, Gaëlle Letort, Rose Bulteau, Christelle Da Silva, Adrien Eichmuller, Anna Francesca Tortorelli, Joséphine Blévinal, Morgane Belle, Julien Dumont, Tristan Piolot and 7 more

Open access · goldFull text read
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Machine Learning Methods to Characterize Mouse and Human Oocytes.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  7. Article
  8. Article
  9. Female fertility and the mammalian egg'sHistology and histopathology · 2024
    Review
  10. Article
  11. Electro-Metabolic Coupling of Cumulus-Oocyte Complex.International journal of molecular sciences · 2024
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Flora CrozetCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSL, Paris, France.
Gaëlle LetortCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSL, Paris, France.ORCID https://orcid.org/0000-0002-5866-0322
Rose BulteauCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSL, Paris, France.
Christelle Da SilvaCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSL, Paris, France.ORCID https://orcid.org/0000-0003-2248-0474
Adrien EichmullerCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSL, Paris, France.
Anna Francesca TortorelliInstitut Curie, PSL Research University, Sorbonne Université, CNRS UMR 3215, INSERM U934, Paris, France.ORCID https://orcid.org/0000-0002-9995-9582
Joséphine BlévinalInstitut de la Vision, UMRS968/UMR7210/UM80, Paris, France.
Morgane BelleInstitut de la Vision, UMRS968/UMR7210/UM80, Paris, France.ORCID https://orcid.org/0000-0003-2081-061X
Julien DumontCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSL, Paris, France.ORCID https://orcid.org/0000-0001-8538-0281
Tristan PiolotCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSL, Paris, France.ORCID https://orcid.org/0000-0001-7270-8591
Aurélien DauphinInstitut Curie, PSL Research University, Sorbonne Université, CNRS UMR 3215, INSERM U934, Paris, France.ORCID https://orcid.org/0000-0001-9744-8458
Fanny CoulpierGenomics Core Facility, Institut de Biologie de l'ENS, Département de biologie, Ecole normale supérieure, CNRS, INSERM, Université PSL, Paris, France.ORCID https://orcid.org/0000-0002-1558-0293
Alain ChédotalInstitut de la Vision, UMRS968/UMR7210/UM80, Paris, France.ORCID https://orcid.org/0000-0001-7577-3794
Jean-Léon MaîtreInstitut Curie, PSL Research University, Sorbonne Université, CNRS UMR 3215, INSERM U934, Paris, France.ORCID https://orcid.org/0000-0002-3688-1474
Marie-Hélène VerlhacCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSL, Paris, France.ORCID https://orcid.org/0000-0001-8377-9010
Hugh J ClarkeDepartment of Obstetrics and Gynecology, McGill University, Montreal, Canada.ORCID https://orcid.org/0000-0003-2626-244X
Marie-Emilie TerretCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSL, Paris, France marie-emilie.terret@college-de-france.fr.ORCID https://orcid.org/0000-0001-5843-925X
Centre Interdisciplinaire de Recherche en Biologie · FRCentre National de la Recherche Scientifique · FRInstitut de la Vision · FRInstitut Pasteur · FRMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oocyte must grow and mature before fertilization, thanks to a close dialogue with the somatic cells that surround it. Part of this communication is through filopodia-like protrusions, called transzonal projections (TZPs), sent by the somatic cells to the oocyte membrane. To investigate the contribution of TZPs to oocyte quality, we impaired their structure by generating a full knockout mouse of the TZP structural component myosin-X (MYO10). Using spinning disk and super-resolution microscopy combined with a machine-learning approach to phenotype oocyte morphology, we show that the lack of

Indexed as

Ovarian FolliclePseudopodiaAnimalsFemaleGerm CellsMiceMyosinsOocytesOogenesisMyo10 protein, mouseMyosins

Identifiers

PMID36944420
PMCPMC10029974
OpenAlexW4328089472

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read106
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.