Evidence map›Paper›PMID 36944718›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2023

Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants.

Elias Jetsonen, Giuliano Didio, Frederike Winkel, Maria Llach Pou, Chloe Boj, Laura Kuczynski-Noyau, Vootele Võikar, Ramon Guirado, Tomi Taira, Sari E Lauri and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Parvalbumin interneurons under stress: converging mechanisms of vulnerability.The international journal of neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 4 countries.

Elias Jetsonen *Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.
Giuliano Didio *Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.
Frederike WinkelNeuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.
Maria Llach PouNeuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-4318-4116
Chloe BojNeuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.
Laura Kuczynski-NoyauNeuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-0175-1135
Vootele VõikarNeuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-4201-8666
Ramon GuiradoNeurobiology Unit, Department of Cell Biology, Interdisciplinary Research Structure for Biotechnology and Biomedicine (BIOTECMED), Universitat de Valencia, Valencia, Spain.
Tomi TairaDepartment of Veterinary Biosciences and Neuroscience Center, University of Helsinki, Helsinki, Finland.
Sari E LauriNeuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-5895-1357
Eero CastrénNeuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland. eero.castren@helsinki.fi.ORCID http://orcid.org/0000-0002-1402-2791
Juzoh UmemoriNeuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland. juzoh.umemori@uef.fi.ORCID http://orcid.org/0000-0003-2595-7362
University of Helsinki · FIUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Critical period-like plasticity (iPlasticity) can be reinstated in the adult brain by several interventions, including drugs and optogenetic modifications. We have demonstrated that a combination of iPlasticity with optimal training improves behaviors related to neuropsychiatric disorders. In this context, the activation of TrkB, a receptor for BDNF, in Parvalbumin-positive (PV

Indexed as

ParvalbuminsReversal LearningAnimalsAntidepressive AgentsFearFluoxetineInterneuronsMiceReceptor, trkBAntidepressive AgentsFluoxetineParvalbuminsReceptor, trkB

Identifiers

PMID36944718
PMCPMC10209093
OpenAlexW4328127676

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.