Evidence map›Paper›PMID 36945189›Full record

ArticleGlia2023

Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination.

Susan L Lindsay, George A McCanney, Jiangshan Zhan, Miriam Scheld, Rebecca Sherrard Smith, Carl S Goodyear, Edwin A Yates, Markus Kipp, Jeremy E Turnbull, Susan C Barnett

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Susan L LindsaySchool of Infection and Immunity, University of Glasgow, 120 University Place, Glasgow, G12 8TA, UK.ORCID 0000-0003-4241-4933
George A McCanneySchool of Infection and Immunity, University of Glasgow, 120 University Place, Glasgow, G12 8TA, UK.
Jiangshan ZhanInstitute of Anatomy, University of Rostock, Gertrudenstrasse 9, 18057, Rostock, Germany.
Miriam ScheldInstitute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, 52074, Aachen, Germany.
Rebecca Sherrard SmithSchool of Infection and Immunity, University of Glasgow, 120 University Place, Glasgow, G12 8TA, UK.
Carl S GoodyearSchool of Infection and Immunity, University of Glasgow, 120 University Place, Glasgow, G12 8TA, UK.ORCID 0000-0001-5926-5941
Edwin A YatesInstitute of Systems, Molecules and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK.
Markus KippInstitute of Anatomy, University of Rostock, Gertrudenstrasse 9, 18057, Rostock, Germany.ORCID 0000-0001-5043-9052
Jeremy E TurnbullInstitute of Systems, Molecules and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK.
Susan C BarnettSchool of Infection and Immunity, University of Glasgow, 120 University Place, Glasgow, G12 8TA, UK.ORCID 0000-0003-1009-0575
University of Glasgow · GBUniversity of Liverpool · GBUniversity of Rostock · DERWTH Aachen University · DE

Funding

Medical Research Council MR/V00381X/1
6 · The paper itself

Abstract

There is an urgent need for therapies that target the multicellular pathology of central nervous system (CNS) disease. Modified, nonanticoagulant heparins mimic the heparan sulfate glycan family and are known regulators of multiple cellular processes. In vitro studies have demonstrated that low sulfated modified heparin mimetics (LS-mHeps) drive repair after CNS demyelination. Herein, we test LS-mHep7 (an in vitro lead compound) in experimental autoimmune encephalomyelitis (EAE) and cuprizone-induced demyelination. In EAE, LS-mHep7 treatment resulted in faster recovery and rapidly reduced inflammation which was accompanied by restoration of animal weight. LS-mHep7 treatment had no effect on remyelination or on OLIG2 positive oligodendrocyte numbers within the corpus callosum in the cuprizone model. Further in vitro investigation confirmed that LS-mHep7 likely mediates its pro-repair effect in the EAE model by sequestering inflammatory cytokines, such as CCL5 which are upregulated during immune-mediated inflammatory attacks. These data support the future clinical translation of this next generation modified heparin as a treatment for CNS diseases with active immune system involvement.

Indexed as

Central Nervous System DiseasesEncephalomyelitis, Autoimmune, ExperimentalAnimalsCorpus CallosumCuprizoneDisease Models, AnimalHeparan SulfateMiceMice, Inbred C57BLMyelin SheathOligodendrogliaSulfatesCuprizoneHeparan SulfateSulfatesCNS repaircuprizoneEAEheparan sulfatemultiple sclerosismyelination

Identifiers

PMID36945189
PMCPMC10952530
OpenAlexW4353020472

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.