Evidence map›Paper›PMID 36945483›Full record

ArticlebioRxiv : the preprint server for biology2023

Identifying Fibrogenic Cells Following Salivary Gland Obstructive Injury.

Amber L Altrieth, Kevin J O'Keefe, Victoria A Gellatly, Joey R Tavarez, Sage M Feminella, Nicholas L Moskwa, Carmalena V Cordi, Judy C Turrieta, Deirdre A Nelson, Melinda Larsen

Open access · greenFull text readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Amber L AltriethDepartment of Biological Sciences and The RNA Institute, University at Albany, State University of New York, Albany, New York, USA.
Kevin J O'KeefeDepartment of Biological Sciences and The RNA Institute, University at Albany, State University of New York, Albany, New York, USA.
Victoria A GellatlyDepartment of Biological Sciences and The RNA Institute, University at Albany, State University of New York, Albany, New York, USA.
Joey R TavarezDepartment of Biological Sciences and The RNA Institute, University at Albany, State University of New York, Albany, New York, USA.
Sage M FeminellaDepartment of Biological Sciences and The RNA Institute, University at Albany, State University of New York, Albany, New York, USA.
Nicholas L MoskwaDepartment of Biological Sciences and The RNA Institute, University at Albany, State University of New York, Albany, New York, USA.
Carmalena V CordiDepartment of Biological Sciences and The RNA Institute, University at Albany, State University of New York, Albany, New York, USA.
Judy C TurrietaDepartment of Biological Sciences and The RNA Institute, University at Albany, State University of New York, Albany, New York, USA.
Deirdre A NelsonDepartment of Biological Sciences and The RNA Institute, University at Albany, State University of New York, Albany, New York, USA.
Melinda LarsenDepartment of Biological Sciences and The RNA Institute, University at Albany, State University of New York, Albany, New York, USA.
Albany State University · US

Funding

Remediating fibrosis for salivary gland regenerationR01DE027953 · NIDCR · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI MELINDA LARSEN · 2019 to 2026
$5.4M
Cellular plasticity in salivary gland regeneration.R01DE030626 · NIDCR · UNIVERSITY OF ROCHESTER · PI LARSEN, MELINDA · 2021 to 2025
$2.3M
Endothelial cell signaling in regenerationR21DE027571 · NIDCR · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI LARSEN, MELINDA · 2018 to 2019
$432k
Angiocrine Factors in Salivary Gland RegenerationF31DE029688 · NIDCR · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI ALTRIETH, AMBER · 2020 to 2023
$78k
NIDCR NIH HHS F31 DE029688NIDCR NIH HHS R01 DE027953NIDCR NIH HHS R01 DE030626NIDCR NIH HHS R21 DE027571
6 · The paper itself

Abstract

Fibrosis results from excess extracellular matrix accumulation, which alters normal tissue architecture and impedes function. In the salivary gland, fibrosis can be induced by irradiation treatment for cancer therapy, Sjögren's Disease, and other causes; however, it is unclear which stromal cells and signals participate in injury responses and disease progression. As hedgehog signaling has been implicated in fibrosis of the salivary gland and other organs, we examined contributions of the hedgehog effector, Gli1, to fibrotic responses in salivary glands. To experimentally induce a fibrotic response in female murine submandibular salivary glands, we performed ductal ligation surgery. We detected a progressive fibrotic response where both extracellular matrix accumulation and actively remodeled collagen trended upwards at 7 days and significantly increased at 14 days post- ligation. Macrophages, which participate in extracellular matrix remodeling, Gli1

Identifiers

PMID36945483
PMCPMC10028956
OpenAlexW4323838954

What Socratic holds

Textfull text, public
LicenceCC BY-ND
measurements read77
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.