Evidence map›Paper›PMID 36945496›Full record

ArticlebioRxiv : the preprint server for biology2023

Exploring the evolution and function of Canoe’s intrinsically disordered region in linking cell-cell junctions to the cytoskeleton during embryonic morphogenesis.

Noah J Gurley, Rachel A Szymanski, Robert H Dowen, T Amber Butcher, Noboru Ishiyama, Mark Peifer

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Noah J GurleyDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
Rachel A SzymanskiDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
Robert H DowenDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
T Amber ButcherDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
Noboru IshiyamaLaunchpad Therapeutics, Inc., One Main Street, Cambridge MA 02142.
Mark PeiferDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
University of North Carolina at Chapel Hill · USLaunchpad Central (United States) · US

Funding

Regulating cell fate and shaping the body plan during morphogenesis and their alteration during oncogenesisR35GM118096 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark A. Peifer · 2016 to 2026
$6.5M
Regulation of lipid homeostasis by proliferative signaling pathwaysR35GM137985 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Robert Houston Dowen · 2020 to 2026
$2.9M
NIGMS NIH HHS R35 GM118096NIGMS NIH HHS R35 GM137985
6 · The paper itself

Abstract

One central question for cell and developmental biologists is defining how epithelial cells can change shape and move during embryonic development without tearing tissues apart. This requires robust yet dynamic connections of cells to one another, via the cell-cell adherens junction, and of junctions to the actin and myosin cytoskeleton, which generates force. The last decade revealed that these connections involve a multivalent network of proteins, rather than a simple linear pathway. We focus on

Identifiers

PMID36945496
PMCPMC10028902
OpenAlexW4323366134

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.