Evidence map›Paper›PMID 36945561›Full record

ArticlebioRxiv : the preprint server for biology2024

β-carotene accelerates the resolution of atherosclerosis in mice.

Ivan Pinos, Johana Coronel, Asma'a Albakri, Amparo Blanco, Patrick McQueen, Donald Molina, JaeYoung Sim, Edward A Fisher, Jaume Amengual

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ivan PinosDivision of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL.
Johana CoronelDepartment of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL.
Asma'a AlbakriDivision of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL.
Amparo BlancoDivision of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL.
Patrick McQueenDivision of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL.
Donald MolinaDepartment of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL.
JaeYoung SimDepartment of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL.
Edward A FisherThe Leon H. Charney Division of Cardiology, Department of Medicine, The Marc and Ruti Bell Program in Vascular Biology, New York University Grossman School of Medicine, NYU Langone Medical Center, NY.ORCID 0000-0001-9802-143X
Jaume AmengualDivision of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL.ORCID 0000-0002-6077-3545
University of Illinois Urbana-Champaign · USNYU Langone Health · US

Funding

To study the role of the low-density lipoprotein receptor on carotenoid biodistribution and excretionR01HL147252 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI AMENGUAL TERRASA, JAIME · 2019 to 2023
$2.1M
NHLBI NIH HHS R01 HL147252
6 · The paper itself

Abstract

β-carotene oxygenase 1 (BCO1) catalyzes the cleavage of β-carotene to form vitamin A. Besides its role in vision, vitamin A regulates the expression of genes involved in lipid metabolism and immune cell differentiation. BCO1 activity is associated with the reduction of plasma cholesterol in humans and mice, while dietary β-carotene reduces hepatic lipid secretion and delays atherosclerosis progression in various experimental models. Here we show that β-carotene also accelerates atherosclerosis resolution in two independent murine models, independently of changes in body weight gain or plasma lipid profile. Experiments in

Indexed as

forkhead box P3 (FoxP3)inflammationRetinoic acid

Identifiers

PMID36945561
PMCPMC10028884
OpenAlexW4323827149

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.