Evidence map›Paper›PMID 36945584›Full record

ArticlebioRxiv : the preprint server for biology2023

Dynamics of an incoherent feedforward loop drive ERK-dependent pattern formation in the early

Emily K Ho, Harrison R Oatman, Sarah E McFann, Liu Yang, Heath E Johnson, Stanislav Y Shvartsman, Jared E Toettcher

Open access · greenFull text readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Emily K HoDepartment of Molecular Biology Princeton University, Princeton NJ 08544.
Harrison R OatmanProgram in Quantitative and Computational Biology Princeton University, Princeton NJ 08544.
Sarah E McFannDepartment of Chemical & Biological Engineering Princeton University, Princeton NJ 08544.
Liu YangLewis Sigler Institute for Integrative Genomics Princeton University, Princeton NJ 08544.
Heath E JohnsonDepartment of Molecular Biology Princeton University, Princeton NJ 08544.
Stanislav Y ShvartsmanDepartment of Molecular Biology Princeton University, Princeton NJ 08544.
Jared E ToettcherDepartment of Molecular Biology Princeton University, Princeton NJ 08544.
Princeton University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Cale Whitworth · 2014 to 2026
$13.5M
Control of the 4D chromatin landscape underlying gene activity during developmentU01DK127429 · NIDDK · PRINCETON UNIVERSITY · PI GREGOR, THOMAS, LEVINE, MICHAEL STEVEN · 2020 to 2024
$3.2M
Collective dynamics in cell clustersR01GM134204 · NIGMS · PRINCETON UNIVERSITY · PI Stanislav Y. Shvartsman · 2019 to 2026
$2.6M
Mechanisms of signal integration in developmental control of organ size and tissue patterningR01HD085870 · NICHD · UNIVERSITY OF MASSACHUSETTS BOSTON · PI VERAKSA, ALEXEY · 2016 to 2020
$1.6M
Optogenetic control of spatio-temporal patterning in early embryogenesisF32GM119297 · NIGMS · PRINCETON UNIVERSITY · PI JOHNSON, HEATH E · 2016 to 2018
$173k
NICHD NIH HHS R01 HD085870NIDDK NIH HHS U01 DK127429NIGMS NIH HHS F32 GM119297NIGMS NIH HHS R01 GM134204NIH HHS P40 OD018537
6 · The paper itself

Abstract

Positional information in developing tissues often takes the form of stripes of gene expression that mark the boundaries of a particular cell type or morphogenetic process. How stripes form is still in many cases poorly understood. Here we use optogenetics and live-cell biosensors to investigate one such pattern: the posterior stripe of

Identifiers

PMID36945584
PMCPMC10028984
OpenAlexW4323818613

What Socratic holds

Textfull text, public
LicenceCC BY
reference markers read3
measurements read19
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.