Evidence map›Paper›PMID 36945588›Full record

ArticlebioRxiv : the preprint server for biology2023

Characterization of extracellular matrix deposited by segmental trabecular meshwork cells.

VijayKrishna Raghunathan, Andrews Nartey, Kamesh Dhamodaran, Hasna Baidouri, Julia A Staverosky, Kate E Keller, Keith Zientek, Ashok Reddy, Ted Acott, Janice A Vranka

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

VijayKrishna RaghunathanDepartment of Basic Sciences, College of Optometry, University of Houston, Houston, Texas.
Andrews NarteyDepartment of Basic Sciences, College of Optometry, University of Houston, Houston, Texas.
Kamesh DhamodaranDepartment of Basic Sciences, College of Optometry, University of Houston, Houston, Texas.
Hasna BaidouriDepartment of Basic Sciences, College of Optometry, University of Houston, Houston, Texas.
Julia A StaveroskyOphthalmology and Visual Sciences, Casey Eye Institute.
Kate E KellerOphthalmology and Visual Sciences, Casey Eye Institute.
Keith ZientekProteomics Shared Resources, Oregon Health & Science University, Portland, Oregon, United States.
Ashok ReddyProteomics Shared Resources, Oregon Health & Science University, Portland, Oregon, United States.
Ted AcottOphthalmology and Visual Sciences, Casey Eye Institute.
Janice A VrankaOphthalmology and Visual Sciences, Casey Eye Institute.
Oregon Health & Science University · USUniversity of Houston · US

Funding

Translational Oncology Research ProgramP30CA069533 · OREGON HEALTH & SCIENCE UNIVERSITY · 1997 to 2025
$10.7M
Proteomics CoreP30EY010572 · OREGON HEALTH & SCIENCE UNIVERSITY · 1995 to 2025
$4.4M
Hair-Bundle ProteinsR01DC002368 · OREGON HEALTH & SCIENCE UNIVERSITY · 1994 to 2025
$2.8M
BIOLOGY OF TRABECULAR RESPONSE TO LASER TRABECULOPLASTYR01EY008247 · OREGON HEALTH AND SCIENCE UNIVERSITY · 1989 to 2005
$2.3M
Extracellular Matrix and Outflow ResistanceR01EY019643 · OREGON HEALTH & SCIENCE UNIVERSITY · 2025 to 2025
$427k
The Aqueous Humor Outflow ResistanceR01EY030238 · OREGON HEALTH & SCIENCE UNIVERSITY · 2025 to 2025
$408k
Thrombospondin-1 in normal and glaucomatous trabecular meshworkR01EY032590 · OREGON HEALTH & SCIENCE UNIVERSITY · 2025 to 2025
$392k
NCI NIH HHS P30 CA069533NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY008247NEI NIH HHS R01 EY019643NEI NIH HHS R01 EY025721NEI NIH HHS R01 EY026048NEI NIH HHS R01 EY030238NEI NIH HHS R01 EY032590NIDCD NIH HHS R01 DC002368
6 · The paper itself

Abstract

Biophysical and biochemical attributes of the extracellular matrix are major determinants of cell fate in homeostasis and disease. Ocular hypertension and glaucoma are diseases where the trabecular meshwork tissue responsible for aqueous humor egress becomes stiffer accompanied by changes in its matrisome in a segmental manner with regions of high or low flow. Prior studies demonstrate these alterations in the matrix are dynamic in response to age and pressure changes. The underlying reason for segmentation or differential response to pressure and stiffening are unknown. This is largely due to a lack of appropriate models (

Identifiers

PMID36945588
PMCPMC10028995
OpenAlexW4323981268

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.