Evidence map›Paper›PMID 36945604›Full record

ArticlemedRxiv : the preprint server for health sciences2023

RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.

Danya J Martell, Hope E Merens, Claudia Fiorini, Alexis Caulier, Jacob C Ulirsch, Robert Ietswaart, Karine Choquet, Giovanna Graziadei, Valentina Brancaleoni, Maria Domenica Cappellini and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Danya J MartellHarvard University, Department of Genetics, Boston, MA.
Hope E MerensHarvard University, Department of Genetics, Boston, MA.
Claudia FioriniDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Alexis CaulierDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Jacob C UlirschDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Robert IetswaartHarvard University, Department of Genetics, Boston, MA.
Karine ChoquetHarvard University, Department of Genetics, Boston, MA.
Giovanna GraziadeiDepartment of Clinical Sciences and Community, University of Milan, IRCCS Ca'Granda Foundation Maggiore Policlinico Hospital, Milan, Italy.
Valentina BrancaleoniDepartment of Clinical Sciences and Community, University of Milan, IRCCS Ca'Granda Foundation Maggiore Policlinico Hospital, Milan, Italy.
Maria Domenica CappelliniDepartment of Clinical Sciences and Community, University of Milan, IRCCS Ca'Granda Foundation Maggiore Policlinico Hospital, Milan, Italy.
Caroline ScottMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Nigel RobertsMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Melanie ProvenOxford Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Noémi Ba RoyMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Christian BabbsMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Douglas R HiggsMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Vijay G SankaranDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
L Stirling ChurchmanHarvard University, Department of Genetics, Boston, MA.
Broad Institute · USHarvard University · USUniversity of Oxford · GBUniversity of Milan · ITJohn Radcliffe Hospital · GBOxford University Hospitals NHS Trust · GB

Funding

TRAINING GRANT IN GENETICST32GM007748 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Anne O'Donnell-Luria, Louise Wilkins-Haug · 1985 to 2026
$12.0M
Mechanisms of Transcriptional Control Revealed by Nascent Transcript SequencingR01HG007173 · NHGRI · HARVARD MEDICAL SCHOOL · PI Lee Stirling Churchman · 2013 to 2026
$6.7M
Systematic Genetic Dissection of Human ErythropoiesisR01DK103794 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Vijay Ganesh Sankaran · 2014 to 2026
$5.9M
Next generation functional genomics of hematology traitsR01HL146500 · NHLBI · UNIVERSITY OF WASHINGTON · PI ALEXANDER P REINER · 2020 to 2026
$5.7M
Discovering the regulatory roles of transcription during erythropoiesis, one nucleotide at a timeF32GM125238 · NIGMS · HARVARD MEDICAL SCHOOL · PI SMART, DANYA J · 2017 to 2019
$184k
NHGRI NIH HHS R01 HG007173NHLBI NIH HHS R01 HL146500NIDDK NIH HHS R01 DK103794NIGMS NIH HHS F32 GM125238NIGMS NIH HHS T32 GM007748
6 · The paper itself

Abstract

The controlled release of promoter-proximal paused RNA polymerase II (Pol II) into productive elongation is a major step in gene regulation. However, functional analysis of Pol II pausing is difficult because factors that regulate pause release are almost all essential. In this study, we identified heterozygous loss-of-function mutations in

Identifiers

PMID36945604
PMCPMC10029049
OpenAlexW4323353638

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.