Evidence map›Paper›PMID 36946298›Full record

ArticlePharmacogenomics2023

Effects of oxycodone pharmacogenetics on postoperative analgesia and related clinical outcomes in children: a pilot prospective study.

Blessed W Aruldhas, Sara K Quinney, Senthil Packiasabapathy, Brian R Overholser, Olivia Raymond, Sahana Sivam, Inesh Sivam, Sanjana Velu, Antoinette Montelibano, Senthilkumar Sadhasivam

Abstract read
In one paragraph

Article in Pharmacogenomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Strategies for Managing Pediatric Fracture Pain: Assessment, Pharmacological, and Non-Pharmacological Interventions.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Blessed W AruldhasDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-2082-6454
Sara K QuinneyDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-6554-0695
Senthil PackiasabapathyDepartment of Anesthesia, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-0248-5430
Brian R OverholserDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0003-3055-9916
Olivia RaymondDepartment of Anesthesiology & Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Sahana SivamNorth Allegheny Intermediate High School, Pittsburgh, PA 15237, USA.
Inesh SivamNorth Allegheny Intermediate High School, Pittsburgh, PA 15237, USA.
Sanjana VeluWilliam Mason High School, Mason, OH 45040, USA.
Antoinette MontelibanoDepartment of Anesthesiology & Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Senthilkumar SadhasivamDepartment of Anesthesia, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-3689-8313

Funding

The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)P30HD106451 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI Lang Li, Sara K Quinney · 2021 to 2026
$24.1M
Perioperative Precision Medicine: Translating Science to Clinical Practice to Improve Safety and Efficacy of Opioids in Neonates, Children and Nursing MothersU01TR003719 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Senthilkumar Sadhasivam · 2022 to 2026
$4.4M
Effects of Opioid Use Disorder in Pregnancy on Long-Term Maternal and Child OutcomesR01HD096800 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SADHASIVAM, SENTHILKUMAR · 2018 to 2022
$3.1M
Pharmacogenetics of Oxycodone, Personalized Care and Persistent Surgical PainR01HD089458 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI SADHASIVAM, SENTHILKUMAR · 2016 to 2020
$2.5M
Bedside prediction of opioid-induced respiratory depression in children with pupillometryR21HD094311 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI SADHASIVAM, SENTHILKUMAR · 2018 to 2019
$433k
NCATS NIH HHS U01 TR003719NICHD NIH HHS R01 HD089458NICHD NIH HHS R01 HD096800NICHD NIH HHS R21 HD094311
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnalgesiaOxycodoneAnalgesics, OpioidChildHumansMorphinePharmacogeneticsPostoperative PainProspective StudiesAnalgesics, OpioidMorphineOxycodoneABCB1analgesiachildrenCOMTCYP2D6CYP3A4hospital stayOPRM1oxycodonepharmacogeneticspharmacokineticsPXR

Identifiers

PMID36946298
PMCPMC10061242

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.