ArticleTranslational vision science & technology2023
Prevalence and Characteristics of Myopia in Adult Non-Human Primates in Southwest China.
Article in Translational vision science & technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Ocular Component Growth From the Cornea to the Sclera in Non-Human Primate Emmetropization.Investigative ophthalmology & visual science · 2026Article
- Spontaneous Pathologic Myopia and Contributing Factors in Nonhuman Primate Models.Translational vision science & technology · 2026Article
- Patterns of transcriptomic aging in the hippocampus of rhesus macaques highlight midlife transitions.GeroScience · 2026Article
- Spontaneous refractive error, ocular biometry and age related lens changes in a population of geriatric rhesus macaques.Scientific reports · 2025Article
- Choroidal Features of Cynomolgus Macaques in Relation to Age and Axial Length.Investigative ophthalmology & visual science · 2025Article
- Pseudomyopia and cycloplegic changes in young cynomolgus macaques.Molecular vision · 2025Article
- Fundus Tessellation and Parapapillary Atrophy, as Ocular Characteristics of Spontaneously High Myopia in Macaques: The Non-Human Primates Eye Study.Translational vision science & technology · 2024Article
- Animal modeling for myopia.Advances in ophthalmology practice and researchReview
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate the prevalence of myopia in a large cohort of adult cynomolgus monkeys (Macaca fascicularis) at Yunnan Province in southwest China and describe the characteristics of myopic rhesus macaque eyes. Methods: A total of 219 cynomolgus monkeys 14.07 ± 2.72 years old (range, 8-21) were randomly recruited for this study. We performed fundus photography and measurements of cycloplegic refractive error (RE) and axial length (AL) on macaques. Results: A total of 429 eyes of 219 macaques were examined. The median RE was -1.25 diopters (D), and the median AL was 18.69 mm. The prevalence of myopia was 62.47%, and one-third of the myopic eyes were highly myopic. The presence of fundus tessellations was higher in myopic eyes than non-myopic eyes (42.54% vs. 6.21%). The cutoff value for the presence of tessellations was -3.52 D for RE and 19.38 mm for AL. In myopic eyes, there were significant differences between grade 1 and grade 3 fundus tessellations on RE (-5.57 ± 2.97 D vs. -8.13 ± 3.51 D) and AL (19.66 ± 0.55 mm vs. 20.60 ± 1.06 mm). Beta-peripapillary atrophy (β-PPA) was found in 48.10% of myopic eyes and 6.83% of non-myopic eyes. The presence of β-PPA is associated with the presence of fundus tessellations, AL, and RE. The presence of β-PPA was higher in grade 3 than grade 1 fundus tessellations (94.4% vs. 76%). Conclusions: More than half of adult cynomolgus monkeys in southwest China are myopic, and one-third of the myopic ones are highly myopic. Similar to humans, tessellated fundi and β-PPA are the characteristic signs of myopic cynomolgus monkeys. Adult cynomolgus monkeys are optimal animal models for research on the pathogenesis of myopia. Translational Relevance: This study not only provides a reference for the refractive state and AL in myopic cynomolgus monkeys but also indicates that adult cynomolgus monkeys with spontaneous myopia are optimal animal models for research on the pathogenesis of myopia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.