Evidence map›Paper›PMID 36947129›Full record

ArticleeLife2023

Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals.

Zane Kliesmete, Lucas Esteban Wange, Beate Vieth, Miriam Esgleas, Jessica Radmer, Matthias Hülsmann, Johanna Geuder, Daniel Richter, Mari Ohnuki, Magdelena Götz and 2 more

Open access · goldFull text read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. The Control of Cortical Folding: Multiple Mechanisms, Multiple Models.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Zane Kliesmete *Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany.
Lucas Esteban Wange *Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany.
Beate ViethAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany.
Miriam EsgleasPhysiological Genomics, BioMedical Center - BMC, Ludwig-Maximilians-Universität, Munich, Germany.
Jessica RadmerAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany.
Matthias HülsmannAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany.
Johanna GeuderAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany.
Daniel RichterAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany.
Mari OhnukiAnthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany.
Magdelena GötzPhysiological Genomics, BioMedical Center - BMC, Ludwig-Maximilians-Universität, Munich, Germany.
Ines Hellmann *Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany.ORCID 0000-0003-0588-1313
Wolfgang Enard *Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany.ORCID 0000-0002-4056-0550
Genomics (United Kingdom) · GBHelmholtz Zentrum München · DEETH Zurich · CH

Funding

Deutsche Forschungsgemeinschaft 407541155Deutsche Forschungsgemeinschaft 458247426
6 · The paper itself

Abstract

Brain size and cortical folding have increased and decreased recurrently during mammalian evolution. Identifying genetic elements whose sequence or functional properties co-evolve with these traits can provide unique information on evolutionary and developmental mechanisms. A good candidate for such a comparative approach is

Indexed as

FerretsNeural Stem CellsAnimalsBrainCell Cycle ProteinsDNA-Binding ProteinsMiceOrgan SizePhylogenyCell Cycle ProteinsDNA-Binding ProteinsTrnp1 protein, mousebrain foldingbrain sizeco-evolutionevolutionary biologyfunctional assaysgeneticsgenomicshumanmammalsmousephylogenetics

Identifiers

PMID36947129
PMCPMC10032658
OpenAlexW4353015303

What Socratic holds

Textfull text, public
LicenceCC BY
reference markers read1
measurements read74
identifiers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.