ArticleCell metabolism2023
Epigenetic dosage identifies two major and functionally distinct β cell subtypes.
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Article in Cell metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- 4-Methylumbelliferone for type 1 diabetes therapy: evidence for β-cell protection via EGFR/PI3K/Akt signaling.Journal of endocrinological investigation · 2026Article
- Temporal single-cell transcriptional dynamics of murine pancreatic islet remodeling during hyperglycaemia progression.Molecular metabolism · 2026Article
- Epigenetic regulation in a high-sugar environment (Review).International journal of molecular medicine · 2026Review
- Liver-derived Indian hedgehog (Ihh) couples fast-feed transition to thermogenic and metabolic homeostasis.Molecular metabolism · 2026Article
- Epigenetic adaptation of beta cells across lifespan and disease.Nature metabolism · 2026Article
- Epigenetic control of PDX1 and NGN3 by a computationally designed PRC2 inhibitor enforces pancreatic endocrine differentiation from pluripotent stem cells.Research square · 2026Article
- CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Age at type 2 diabetes onset, HOMA-derived indices and risks of diabetic retinopathy: a real-world cross-sectional study.Frontiers in endocrinology · 2026Article
- Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes.Nature metabolism · 2026Article
- The role of the beta cell in type 2 diabetes: new findings from the last 5 years.Diabetologia · 2025Review
- Stem-cell-derived beta cells mature metabolically upon murine engraftment.Diabetologia · 2025Article
- Interpretable machine learning-guided single-cell mapping deciphers multi-lineage pancreatic dysregulation in type 2 diabetes.Cardiovascular diabetology · 2025Article
- Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors.Nature communications · 2025Article
- Aere perennius: how chromatin fidelity is maintained and lost in disease.NAR molecular medicine · 2025Review
- Islet single-cell transcriptomic profiling during obesity-induced beta cell expansion in female mice.iScience · 2025Article
- Signal transduction pathways controllingiScience · 2025Article
- Biphasic glucose-stimulated insulin secretion over decades: a journey from measurements and modeling to mechanistic insights.Life metabolism · 2025Review
- β-cell heterogeneity and molecular plasticity in type 2 diabetes: multi-omics perspectives and the role of gut microbiota.Frontiers in cell and developmental biology · 2025Review
- From stem cells to pancreatic β-cells: strategies, applications, and potential treatments for diabetes.Molecular and cellular biochemistry · 2025Review
- Exploring pancreatic beta-cell subgroups and their connectivity.Nature metabolism · 2024Review
Corrections and comments
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Authors and funding
20 authors.
Erez DrorDepartment of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany. Electronic address: dror@ie-freiburg.mpg.de.
Luca FagnocchiDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Vanessa WegertDepartment of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Stefanos ApostleDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Brooke GrimaldiDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Tim GruberDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Ilaria PanzeriDepartment of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Steffen HeyneDepartment of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Kira Daniela HöfflerDepartment of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Victor KreinerDepartment of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Reagan ChingDepartment of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Tess Tsai-Hsiu LuDepartment of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Ayush SemwalDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Ben JohnsonDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Parijat SenapatiDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Adelheid LempradlDepartment of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Dustin SchonesDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Axel ImhofBiomedical Center Munich, Ludwig Maximilian University of Munich, 82152 Planegg-Martinsried, Germany.
Hui ShenDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
John Andrew PospisilikDepartment of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: andrew.pospisilik@vai.org.
Funding
Master regulators of unexplained variation in disease riskR01HG012444 · NHGRI · VAN ANDEL RESEARCH INSTITUTE · PI NADEAU, JOSEPH H., POSPISILIK, JOHN ANDREW · 2021 to 2025
$9.6MCancer Epigenetics Training (CET) ProgramT32CA251066 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI Scott Rothbart · 2021 to 2026
$2.4MEpigenetic control and probabilistic disease programmingR21HG011964 · NHGRI · VAN ANDEL RESEARCH INSTITUTE · PI POSPISILIK, JOHN ANDREW · 2021 to 2021
$523kNCI NIH HHS T32 CA251066NHGRI NIH HHS R01 HG012444NHGRI NIH HHS R21 HG011964
Abstract
The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here, we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β
Indexed as
Diabetes Mellitus, Type 2Insulin-Secreting CellsEpigenesis, GeneticHistonesHumansInsulin SecretionHistonesbeta cellsbivalent genescell heterogeneitychromatin organizationepigeneticsH3K27me3insulinpancreatic isletsingle cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.