Evidence map›Paper›PMID 36948494›Full record

ArticleThe journal of allergy and clinical immunology. In practice2023

Impact of Penicillin Allergy Label on Clinical Outcomes of Pneumonia in Children.

Lauren W Kaminsky, Sarah Al-Obaydi, Rezhan H Hussein, Alexandra A Horwitz, Taha Al-Shaikhly

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of allergy and clinical immunology. In practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Penicillin allergy labels increase risks of MRSA colonization, surgical site infections, and mortality.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lauren W KaminskySection of Allergy, Asthma and Immunology, Department of Medicine, Penn State College of Medicine, Hershey, Pa.
Sarah Al-ObaydiDivision of Hospitalist Medicine, Department of Medicine, Penn State College of Medicine, Hershey, Pa.
Rezhan H HusseinDivision of Infectious Diseases, Department of Medicine, Penn State College of Medicine, Hershey, Pa.
Alexandra A HorwitzDivision of Allergy-Immunology, Department of Pediatrics, Penn State College of Medicine, Hershey, Pa.
Taha Al-ShaikhlySection of Allergy, Asthma and Immunology, Department of Medicine, Penn State College of Medicine, Hershey, Pa. Electronic address: talshaikhly@pennstatehealth.psu.edu.
Penn State Milton S. Hershey Medical Center · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
NCATS NIH HHS UL1 TR002014
6 · The paper itself

Abstract

backgroundPenicillin (PCN) allergy label, reported in approximately 5% of children, influences antibiotic choice and prolongs hospital stay. To our knowledge, the impact of PCN allergy label on clinical outcomes of pneumonia in children is not well characterized.

objectivesTo investigate the impact of PCN allergy label on clinical outcomes of pneumonia in children.

methodsIn this propensity score-matched cohort study, we used the TriNetX research network, a population-based database, to compare the 30-day risk of hospitalization, need for intensive level of care, and acute respiratory failure from pneumonia between pediatric patients (aged 1-17 years) with and without a PCN allergy label after matching the 2 cohorts for demographic and medical comorbidities. Antibiotic prescription patterns were also contrasted.

resultsWhen comparing 3793 pediatric patients with pneumonia labeled with a PCN allergy with matched children without a PCN allergy label, PCN allergy label was associated with a higher risk of hospitalization (relative risk [RR], 1.15; 95% confidence interval [CI], 1.07-1.23), acute respiratory failure (RR, 1.27; 95% CI, 1.17-1.39), and need for intensive level of care (RR, 1.46; 95% CI, 1.15-1.84). PCN allergy label resulted in overutilization of broader-spectrum antibiotics and increased complications including cutaneous drug reactions (RR, 2.43; 95% CI, 1.31-4.52) and Clostridioides difficile infection (RR, 2.25; 95% CI, 1.14-4.44).

conclusionChildren with a PCN allergy label are more likely to be hospitalized, receive broader-spectrum antibiotics, and develop acute respiratory failure from pneumonia. Delabeling may offer a way to lessen morbidity from pneumonia in children.

Indexed as

Drug HypersensitivityHypersensitivityPneumoniaRespiratory InsufficiencyAnti-Bacterial AgentsChildCohort StudiesHumansPenicillinsAnti-Bacterial AgentsPenicillinsAdverse drug reactionsBroad-spectrum antibioticsChildrenHospitalizationPenicillin allergyPenicillin allergy delabelingPneumoniaRespiratory failure

Identifiers

PMID36948494
PMCPMC10272071
OpenAlexW4328107263

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.