Evidence map›Paper›PMID 36949078›Full record

ArticleNature communications2023

Interoperable slide microscopy viewer and annotation tool for imaging data science and computational pathology.

Chris Gorman, Davide Punzo, Igor Octaviano, Steven Pieper, William J R Longabaugh, David A Clunie, Ron Kikinis, Andrey Y Fedorov, Markus D Herrmann

Full text read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Report on the 2025 DICOM WSI Connectathon.Journal of pathology informatics · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. The Iris File Extension.Journal of pathology informatics · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Iris: A Next Generation Digital Pathology Rendering Engine.Journal of pathology informatics · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chris GormanDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Davide PunzoRadical Imaging, Boston, MA, USA.ORCID 0000-0003-1624-5814
Igor OctavianoRadical Imaging, Boston, MA, USA.ORCID 0000-0002-6455-1480
Steven PieperIsomics Inc, Cambridge, MA, USA.
William J R LongabaughInstitute for Systems Biology, Seattle, WA, USA.
David A CluniePixelMed Publishing LLC, Bangor, PA, USA.ORCID 0000-0002-2406-1145
Ron KikinisDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Andrey Y FedorovDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. afedorov@bwh.harvard.edu.
Markus D HerrmannDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. mdherrmann@mgh.harvard.edu.ORCID 0000-0002-7257-9205

Funding

NCI NIH HHS HHSN261201500003IU.S. Department of Health & Human Services | National Institutes of Health (NIH) HHSN2612015000031
6 · The paper itself

Abstract

The exchange of large and complex slide microscopy imaging data in biomedical research and pathology practice is impeded by a lack of data standardization and interoperability, which is detrimental to the reproducibility of scientific findings and clinical integration of technological innovations. We introduce Slim, an open-source, web-based slide microscopy viewer that implements the internationally accepted Digital Imaging and Communications in Medicine (DICOM) standard to achieve interoperability with a multitude of existing medical imaging systems. We showcase the capabilities of Slim as the slide microscopy viewer of the NCI Imaging Data Commons and demonstrate how the viewer enables interactive visualization of traditional brightfield microscopy and highly-multiplexed immunofluorescence microscopy images from The Cancer Genome Atlas and Human Tissue Atlas Network, respectively, using standard DICOMweb services. We further show how Slim enables the collection of standardized image annotations for the development or validation of machine learning models and the visual interpretation of model inference results in the form of segmentation masks, spatial heat maps, or image-derived measurements.

Indexed as

Data ScienceMicroscopyHumansReproducibility of Results

Identifiers

PMID36949078
PMCPMC10033920

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read2
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.