Evidence map›Paper›PMID 36949142›Full record

ArticleNature communications2023

Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer's disease.

Annamaria Lia, Gabriele Sansevero, Angela Chiavegato, Miriana Sbrissa, Diana Pendin, Letizia Mariotti, Tullio Pozzan, Nicoletta Berardi, Giorgio Carmignoto, Cristina Fasolato and 1 more

Open access · goldFull text read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  6. Prolonged systemic inflammation worsens impairments to astrocyte CaAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  7. Review
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  9. Astrocyte CaBiomolecules · 2026
    Review
  10. Review
  11. Article
  12. Calcium Imaging Studies in Enteric Glia.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  13. Review
  14. Prolonged systemic inflammation worsens impairments to astrocyte CabioRxiv : the preprint server for biology · 2025
    Article
  15. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Annamaria Lia *Neuroscience Institute, National Research Council (CNR), Padua, Italy.ORCID 0000-0001-5465-9941
Gabriele Sansevero *Neuroscience Institute, National Research Council (CNR), Pisa, Italy.ORCID 0000-0003-0562-5459
Angela ChiavegatoDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Miriana SbrissaDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Diana PendinNeuroscience Institute, National Research Council (CNR), Padua, Italy.ORCID 0000-0003-2827-935X
Letizia MariottiNeuroscience Institute, National Research Council (CNR), Padua, Italy.
Tullio PozzanNeuroscience Institute, National Research Council (CNR), Padua, Italy.ORCID 0000-0002-0498-2641
Nicoletta BerardiNeuroscience Institute, National Research Council (CNR), Pisa, Italy.
Giorgio CarmignotoNeuroscience Institute, National Research Council (CNR), Padua, Italy. gcarmi@bio.unipd.it.ORCID 0000-0003-3063-6774
Cristina FasolatoDepartment of Biomedical Sciences, University of Padua, Padua, Italy. cristina.fasolato@unipd.it.
Micaela ZontaNeuroscience Institute, National Research Council (CNR), Padua, Italy. micaela.zonta@cnr.it.ORCID 0000-0002-9982-6405
University of Padua · ITNeuroscience Institute · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium dynamics in astrocytes represent a fundamental signal that through gliotransmitter release regulates synaptic plasticity and behaviour. Here we present a longitudinal study in the PS2APP mouse model of Alzheimer's disease (AD) linking astrocyte Ca

Indexed as

Alzheimer DiseaseAnimalsAstrocytesCalciumCalcium SignalingFemaleLongitudinal StudiesMemory DisordersMiceNeuronal PlasticityStromal Interaction Molecule 1CalciumStim1 protein, mouseStromal Interaction Molecule 1

Identifiers

PMID36949142
PMCPMC10033875
OpenAlexW4353091692

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read72
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.