Evidence map›Paper›PMID 36949307›Full record

ArticleAdvances in experimental medicine and biology2023

Animal Inflammation-Based Models of Neuropsychiatric Disorders.

Konstantin A Demin, Konstantin A Zabegalov, Tatiana O Kolesnikova, David S Galstyan, Yuriy M H B Kositsyn, Fabiano V Costa, Murilo S de Abreu, Allan V Kalueff

Abstract read
PubMed Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Konstantin A DeminNeurobiology Program, Sirius University of Science and Technology, Sochi, Russia.
Konstantin A ZabegalovNeurobiology Program, Sirius University of Science and Technology, Sochi, Russia.
Tatiana O KolesnikovaNeurobiology Program, Sirius University of Science and Technology, Sochi, Russia.
David S GalstyanInstitute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.
Yuriy M H B KositsynInstitute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
Fabiano V CostaNeurobiology Program, Sirius University of Science and Technology, Sochi, Russia.
Murilo S de AbreuLaboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.
Allan V KalueffNeurobiology Program, Sirius University of Science and Technology, Sochi, Russia.
Sirius University of Science and Technology · RUFederal Almazov North-West Medical Research Centre · RUMinistry of Health of the Russian Federation · RUMoscow Institute of Physics and Technology · RUNovosibirsk State University · RUSt Petersburg University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mounting evidence links psychiatric disorders to central and systemic inflammation. Experimental (animal) models of psychiatric disorders are important tools for translational biopsychiatry research and CNS drug discovery. Current experimental models, most typically involving rodents, continue to reveal shared fundamental pathological pathways and biomarkers underlying the pathogenetic link between brain illnesses and neuroinflammation. Recent data also show that various proinflammatory factors can alter brain neurochemistry, modulating the levels of neurohormones and neurotrophins in neurons and microglia. The role of "active" glia in releasing a wide range of proinflammatory cytokines also implicates glial cells in various psychiatric disorders. Here, we discuss recent animal inflammation-related models of psychiatric disorders, focusing on their translational perspectives and the use of some novel promising model organisms (zebrafish), to better understand the evolutionally conservative role of inflammation in neuropsychiatric conditions.

Indexed as

InflammationZebrafishAnimalsBrainMicrogliaModels, AnimalNeurogliaAnimal modelsModel organismsNeurodegenerationNeuroinflammationRodentsZebrafish

Identifiers

PMID36949307
OpenAlexW4360584673

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.